Phantom Limb Clinical Trial
Official title:
Study to Identify the Genetic Variations Associated With Phantom Limb Pain
The purpose of this study is to determine if there is a genetic component to phantom limb pain. DNA will be analyzed for single nucleotide polymorphisms (SNPs) between the control and phantom limb pain group. Total RNA will also be isolated and profiled to asses the degree to which our gene(s) of interest are expressed in the presence or absence of phantom limb pain. Some proteins, such as inflammatory antibodies or the neurotrophin brain-derived neurotrophic factor (BDNF), will also be assessed for their association(s) with phantom limb pain.
Most patients (90-95%)with major limb amputations experience a phantom limb--the vivid
impression that the limb is still present. In many cases, the sensation is painful for
reasons that are currently not well understood. A small subset of amputees (<10%) never
experience phantom limb pain (PLP), the painful sensation felt in the amputated limb. This
difference suggests that there may be a genetic component that precludes some patients from
ever experiencing PLP. Understanding the genetic components of PLP may help in predicting
which patients will experience PLP and which amputees will respond to the various treatment
options available.
In order to understand the genetic aspects and ultimately develop more effective treatment
options in the future, patients with and without PLP will be asked to give 30 mls of blood
after overnight fasting. These blood samples will be de-identified and sent to the National
Institutes of Health (NIH) in Bethesda, Maryland, where all of the genetic analyses will take
place.
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