Personality Disorders Clinical Trial
Official title:
Pharmacology of Cognition in Schizotypal Personality Disorder: Guanfacine for Cognitive Symptoms in Schizotypal Personality Disorder
This study will determine the effectiveness of guanfacine in improving cognitive and functional impairments in schizotypal personality disorder.
Schizotypal personality disorder is a psychiatric condition that is characterized by
deficiencies in interpersonal relationships and disturbances in thought patterns,
appearance, and behavior. This disorder is different from schizophrenia. While some of the
symptoms of the two disorders are similar, such as the tendency to have unusual beliefs and
behaviors, people with schizotypal personality disorder do not experience hallucinations and
are not significantly disconnected from reality, both of which are signature symptoms of
schizophrenia. Guanfacine is a drug that is often used to treat high blood pressure and
attention deficit hyperactivity disorder. There is evidence that guanfacine enhances
cognition and diminishes impulsivity. This study will determine the effectiveness of
guanfacine in improving symptoms of schizotypal personality disorder.
Participants in this 6-week, double-blind study will be randomly assigned to receive either
guanfacine or placebo. Participants receiving guanfacine will remain on the drug for the
duration of the study. The other participants will receive placebo for the duration of the
study. Guanfacine dosages will not exceed 2 mg per day. All participants will report to the
study site weekly for assessments of vital signs, study compliance, medication side effects,
and psychological symptoms. Additional cognitive testing will be performed at week 6. Upon
study completion, patients will return for a follow-up assessment.
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