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Persian Gulf Syndrome clinical trials

View clinical trials related to Persian Gulf Syndrome.

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NCT ID: NCT05736146 Recruiting - Gulf War Illness Clinical Trials

Validating Gulf War Illness Blood Biomarkers

Start date: June 30, 2022
Phase:
Study type: Observational

The investigators goals are to identify blood lipids/metabolites that correlate with cognitive decline in the presence of the APOE ε4 allele among veterans with GWI. To determine the effect of dietary, medical and biological factors that influence lipid and metabolites in blood from GW veterans. To identify blood lipid/metabolite profiles that correlate with bioenergetics deficits and glial activation in the brains of GWI. To validate blood biomarker signatures of GWI using APOE genotyping and blood lipids/metabolites that correlate with the CNS dysfunction in GWI.

NCT ID: NCT05675878 Recruiting - Gulf War Illness Clinical Trials

Confirmation of Diet as a Treatment for Gulf War Illness

Start date: March 1, 2023
Phase: Phase 3
Study type: Interventional

This clinical trial aims to confirm previous findings from a smaller study which demonstrated significant improvements in all symptoms among veterans with Gulf War Illness after one month on the dietary intervention. The main objectives of this study are: 1) to confirm previous findings of treatment response to the diet in a larger and more diverse group; 2) to examine how changes in the nervous system may be the reason for improvement; and 3) to identify markers which change in the blood after one month on the diet. Participants will have baseline measures collected and then will be randomized into the intervention or wait-listed control group, which they will follow for one month before being reassessed.

NCT ID: NCT05355272 Recruiting - Clinical trials for Adult Growth Hormone Deficiency

Growth Hormone Replacement in Veterans With GWI and AGHD (GWIT)

GWIT
Start date: February 12, 2024
Phase: Phase 2
Study type: Interventional

The goal of the GWIT Study is to assess whether growth hormone replacement therapy is a safe and effective treatment for veterans with Gulf War Illness (GWI) and adult growth hormone deficiency (AGHD). The main questions the study aims to answer are: 1. Is growth hormone effective at reducing fat in the trunk of the body and symptoms of GWI among veterans with GWI and growth hormone deficiency? 2. Do the results of the study suggest there is merit in pursuing a larger trial to examine the efficacy of growth hormone as a treatment for growth hormone deficiency among veterans with Gulf War Illness? To determine eligibility for the study, veterans will be asked to complete several assessments including questionnaires, blood tests, and a scan of the brain. Participants who qualify for the study will receive recombinant human growth hormone for 6-months. A body composition scan will be performed at Day1, Day 90, and Day 180 of the intervention. Questionnaires and cognitive tests will also be collected before and after the trial.

NCT ID: NCT04987775 Recruiting - Gulf War Syndrome Clinical Trials

GWICTIC: NAC Mechanistic Study in Gulf War Veterans

NAC
Start date: November 30, 2023
Phase: Early Phase 1
Study type: Interventional

This mechanistic study will test if NAC affects chronic oxidative stress and depletion of antioxidants in GWI participants. Blood specimen collection and neuroimaging will be used to determine whether NAC affects serum glutathione (GSH) concentration and oxidative stress in the CNS when compared to placebo.

NCT ID: NCT04255498 Recruiting - Gulf War Illness Clinical Trials

Understanding GWI: Integrative Modeling

Start date: October 30, 2017
Phase: Phase 1
Study type: Interventional

The investigator proposes to perform a Phase I study assessing safety, efficacy, and biomarker response to the therapeutic interventions of Etanercept followed by mifepristone for veterans with Gulf War Illness. The investigator will conduct and repeat the exercise challenge before treatment and on therapy to assess the impact of the interventions on homeostatic regulation and the dynamic model identified in prior studies.

NCT ID: NCT04182659 Recruiting - Headache Clinical Trials

Long Term Efficacy of Neuronavigation Guided rTMS in Alleviating Gulf War Illness Related Headaches and Pain Symptoms

Start date: October 1, 2019
Phase: N/A
Study type: Interventional

This study aims to look at the long term efficacy of using repetitive transcranial magnetic stimulation (rTMS) in relieving Gulf War Illness related headaches and pain.

NCT ID: NCT02848417 Recruiting - Gulf War Syndrome Clinical Trials

Glutathione vs. Curcumin Clinical Trial

Glutathione
Start date: April 2016
Phase: Phase 1/Phase 2
Study type: Interventional

The investigator proposes to perform a phase I/II study comparing two nutraceuticals and placebo that target mediators identified in the investigator's prior dynamic modeling study of Gulf War Illness (GWI). The investigator will repeat the dynamic modeling before treatment and on therapy to assess the modeling and the impact of the interventions on the homeostatic networks that have identified, with an added focus on the glutathione/redox system.

NCT ID: NCT00956150 Recruiting - Gulf War Syndrome Clinical Trials

Bacterial Overgrowth Associated With Chronic Multisymptom Illness Complex

Start date: April 2009
Phase: Phase 1
Study type: Interventional

The adverse impact of Gulf War Syndrome (GWS) on the health of veterans and on the resources of the VA Healthcare System underscores the need to resolve its underlying cause. In response, the investigators propose to investigate the central hypothesis that gut bacteria may be responsible for symptoms associated with GWS. The investigators will enroll a total of 120 patients with GWS and 90 healthy controls.