A Phase I Study Evaluating SCB-313 for the Treatment of Subjects With

Clinical Trial Summary

To evaluate the safety and tolerability of SCB-313 in patients with peritoneal carcinomatosisa, to determine the maximum tolerated dose (MTD) and/or extended study recommended dose (RDE) for SCB-313 intraperitoneal injection, providing a basis for dosing regimen and dose choosing in clinical trial subsequently.

See also
Status	Clinical Trial	Phase
Terminated	`NCT04826432` - Pasireotide to Reduce Clinically Relevant Digestive Leakage After Complete Cytoreductive Surgery (CRS) Plus Hyperthermic Intra-Peritoneal Chemotherapy (HIPEC) for Peritoneal Carcinomatosis	Phase 2
Recruiting	`NCT03127774` - Surgery and Heated Intraperitoneal Chemotherapy for Adrenocortical Carcinoma	Phase 2
Recruiting	`NCT04024917` - Impact of Cardiac Coherence on Anxiety in Patients Operated on for a Peritoneal Carcinosis	N/A
Active, not recruiting	`NCT03508570` - Nivolumab With or Without Ipilimumab in Treating Patients With Recurrent or High Grade Gynecologic Cancer With Metastatic Peritoneal Carcinomatosis	Phase 1
Not yet recruiting	`NCT04352894` - Intraoperative ICG Fluorescence Imaging for Peritoneal Carcinomatosis Detection	N/A
Completed	`NCT05547568` - A Nomogram to Predict Major Postoperative Complications After Cytoreductive Surgery and HIPEC Based on Pre and Peroperative Criteria: Which Patient Require Intensive Monitoring?
Completed	`NCT06318793` - Preoperative Inflammatory Markers Predict Postoperative Complications After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Colorectal Carcinomatosis
Terminated	`NCT01683864` - Randomized Controlled Trial to Prevent Peritoneal Seeding in Gastric Cancer	Phase 2/Phase 3
Recruiting	`NCT04547725` - Complete Cytoreduction Followed by IP and Systemic Chemotherapies for Gastric Cancer With Peritoneal Carcinomatosis	N/A
Completed	`NCT03304210` - PIPAC Nab-pac for Stomach, Pancreas, Breast and Ovarian Cancer	Phase 1
Withdrawn	`NCT03682744` - CAR-T Intraperitoneal Infusions for CEA-Expressing Adenocarcinoma Peritoneal Metastases or Malignant Ascites (IPC)	Phase 1
Recruiting	`NCT05623787` - Diagnostic Value of Diffusion-weighted Magnetic Resonance in High-risk Colorectal and Appendiceal Neoplasms	N/A
Recruiting	`NCT05063019` - Role of Magnetic Resonance Enterography for Predicting Peritoneal Cancer Index	N/A
Completed	`NCT02891447` - Heated Mitomycin and Cisplatin During Surgery in Treating Patients With Stomach or Gastroesophageal Cancer	Phase 2
Recruiting	`NCT04231175` - Dedicated MR Imaging vs Surgical Staging of Peritoneal Carcinomatosis in Colorectal Cancer	N/A
Not yet recruiting	`NCT04734691` - Second Line Oxaliplatin Based Chemotherapy Alone Versus Oxaliplatin Based PIPAC and Chemotherapy in Colorectal Peritoneal Carcinomatosis : A Phase II Randomize Mutli-centric Study	Phase 2
Recruiting	`NCT04108936` - Longitudinal Study of CRS/HIPEC for Peritoneal Carcinomatoses
Completed	`NCT02604784` - Study of Efficacy and Safety of Laparoscopic Intra-abdominal Chemotherapy (PIPAC) Performed in Patients With Peritoneal Carcinomatosis From Colorectal, Ovarian, Gastric Cancer and Primary Peritoneal Tumors	Phase 1/Phase 2
Completed	`NCT01764789` - Stress Reduction in Improving Quality of Life in Patients With Recurrent Gynecologic or Breast Cancer	N/A
Terminated	`NCT01540344` - Combined Anticancer Treatment of Advanced Colon Cancer	Phase 2

NCT number	NCT04047771
Study type	Interventional
Source	Sichuan Clover Biopharmaceuticals, Inc.
Contact
Status	Terminated
Phase	Phase 1
Start date	September 10, 2019
Completion date	May 5, 2022

A Phase I Study Evaluating SCB-313 for the Treatment of Subjects With Peritoneal Carcinomatosis

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms