Mechanisms of Neuropathic Pain: Investigation by Contact Heat Evoked Potential

Peripheral Nerve Diseases Clinical Trial

Official title:

Mechanisms of Neuropathic Pain: Investigation by Contact Heat Evoked Potential

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT00173420
• Other study ID #: 9461700654
• Status: Recruiting
• Phase: N/A
• First received: September 12, 2005
• Last updated: October 22, 2007
• Start date: June 2005

Study information

• Verified date: June 2005
• Source: National Taiwan University Hospital
• Contact: Sung-Tsang Hsieh, PhD
• Phone: 886-2-23123456
• Email: sthsieh[@]ha.mc.ntu.edu.tw
• Is FDA regulated: No
• Health authority: Taiwan: Department of Health
• Study type: Observational

Clinical Trial Summary

In order to clarify the normal components of thermal and painful evoked potentials by heat in normal subjects of both genders and different age group, to clarify the effect of specific anatomy in pain transduction, transmission and modification, and to establish the effect of peripheral nerve and their terminal free ending on the nociceptive transduction, the investigators will use heat stimulation on normal controls and patients with neurological diseases to clarify such issues.

Description:

Only a few studies focus on clinical diseases like neuropathic pain or neurogenic pain. Little is known about the differences between normal and pathogenic pain processing. It is an opportunity to apply EEG, ERPs in the clinical fields. In many clinical conditions, brain lesions provide a chance to study the possible roles of one neural structure in pain integration and processing. In addition the applications of EEG/ERPs on clinical conditions may be help in the understanding about mechanism and genesis of pain in pathogenic conditions, the diagnosis of pathogenic pain, and the therapeutic aspects of these abnormal pain senses.

One limit in the study of human pain is the inappropriate stimulation method. Evoked potentials by contact heat have previously been difficult to elicit due to slow temperature rise times associated with thermal stimulators. However recently, the CHEPS (Contact Heat-Evoked Potential Stimulator) is developed, which uses a newly developed heat-foil technology and can create a rapid heating rate (up to 70°C/sec). The baseline and peak temperature and the rising time can be precisely controlled. It provides a non-invasive technique in the investigation of human pain activation related to thermal and nociceptive pathways involved in pain processing. Unlike the heat stimulation delivered by laser, CHEPS can deliver noxious thermal stimuli repeatedly to a large area of skin to evoke a pain response of A-Delta and C fibers. In addition the rate of stimulation can be rapid to lead to the effect of temporal summation. When used with an EEG recording system, a patient's responses to pain perception and evoked potentials (EPs) can be recorded, which provide objective information about integrity of the nociceptive afferents of peripheral nerve system, spinal cord, as well as the brain response of different structures. The CHEPS provide the investigators a practical and convenient tool in clinical application to study pain. The investigators will use the CHEPS as stimulation for studying the heat evoked potentials and analyze the difference between the normal subjects and patients with peripheral nerve diseases. These might help to clarify the mechanism of neuropathic pain.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 15 Years and older

Eligibility

Inclusion Criteria:

• Patients with peripheral nerve diseases or other neurological diseased with sensory disturbance

• Normal subjects without:

• Systemic disease like diabetes mellitus, renal disease or other systemic diseases

• Abnormal neurological symptoms or signs

• Psychological disease like affective disorders or psychosis.

Study Design

N/A

Related Conditions & MeSH terms

• Nervous System Diseases
• Neuralgia
• Peripheral Nerve Diseases
• Peripheral Nervous System Diseases

Locations

Country	Name	City	State
Taiwan	Department of Anatomy and Cell Biology, National Taiwan University College of Medicine	Taipei

Sponsors (1)

Lead Sponsor	Collaborator
National Taiwan University Hospital

Country where clinical trial is conducted

Taiwan,