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Utility of Sortilin as a Biomarker of Restenosis After Lower Extremity Endovascular Revascularization

Peripheral Artery Disease Clinical Trial

Official title:
Utility of Sortilin as a Biomarker of Restenosis After Lower Extremity Endovascular Revascularization in a Cohort of Diabetic Patients With Peripheral Artery Disease and Chronic Limb-threatening Ischemia

Clinical Trial Summary

Sortilin is a 95-kDa protein related to circulating cholesterol. It is found inside different cell types and circulating in blood and it has been associated with the risk of atherosclerosis development and cardiovascular diseases. The goal of this observational study is to evaluate the potential use of circulating sortilin as a biomarker of vascular adverse outcomes in patients with peripheral artery disease (PAD) and chronic limb-threatening ischemia (CLTI) requiring a procedure of endovascular revascularization. The main questions it aims to answer are: - association between sortilin serum levels and risk of restenosis after lower extremity revascularization. - association between sortilin serum levels and acute limb ischemia, major vascular amputations, and limb-threatening ischemia needing for urgent revascularization after lower extremity revascularization. Patients with PAD and CLTI requiring lower extremity endovascular revascularization will undergo blood sampling for the dosage of circulating sortilin before the endovascular procedure. Incidence of restenosis and acute limb ischemia, major vascular amputations, and limb-threatening ischemia needing for urgent revascularization will be collected in a 12-months follow-up and will be associated with sortilin serum levels at baseline.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05759130
Study type Observational
Source Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Contact Andrea Flex, MD, PhD
Phone +39 06 3015 4293
Email andrea.flex@policlinicogemelli.it
Status Recruiting
Phase
Start date October 24, 2019
Completion date October 31, 2024
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