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Hepatocyte Growth Factor to Improve Functioning in PAD — HI-PAD  

Peripheral Artery Disease Clinical Trial

Official title:
Hepatocyte Growth Factor to Improve Functioning in Peripheral Artery Disease: The HI-PAD Study

Clinical Trial Summary

HI-PAD is a placebo controlled double-blind randomized pilot clinical trial to determine whether VM202 may improve walking ability in people with lower extremity peripheral artery disease (PAD).

Clinical Trial Description

The HI-PAD study will randomize 39 people age 55 and older with PAD who do not have critical limb ischemia. The primary outcome is change in the six-minute walk distance at 6-month follow-up after the first study drug injection. A secondary outcome in change in six-minute walk distance at 3-month follow-up. Additional secondary outcomes are pain-free and maximal treadmill walking distance, calf biopsy measures of skeletal muscle regeneration, capillary density, and autophagy, and MRI-measured calf muscle perfusion at three-month follow-up. Investigators will also measure change in six-minute walk distance at 12-month follow-up. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03363165
Study type Interventional
Source Northwestern University
Contact
Status Completed
Phase Phase 2
Start date January 1, 2018
Completion date September 5, 2023
View Details
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