Clinical Trial Details
— Status: Completed
Administrative data
| NCT number |
NCT05552079 |
| Other study ID # |
2019.571 |
| Secondary ID |
|
| Status |
Completed |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
January 21, 2020 |
| Est. completion date |
August 28, 2020 |
Study information
| Verified date |
September 2022 |
| Source |
Chinese University of Hong Kong |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
Peripheral arterial disease (PAD) is one of the most common cardiovascular diseases in
developed countries [1] and is an emerging problem in developing countries [2, 3]. The
prevalence of PAD in European population studies ranged from 3.6 to 9.2 % and 10-20 % in
those aged over 70 years [4]. In a recent meta-analysis, the prevalence of PAD in China
increased gradually by age until mid-60s, after which the increase accelerated. In the early
stages, PAD is mostly silent. With the progression of disease, it may manifest as
intermittent claudication, pain at rest, non-healing ulcer and gangrene resulting in
lower-extremity amputation [5]. PAD is a major cause of disability, loss of employment, and
lifestyle changes, and is a marker for systemic atherosclerotic diseases. Patients with
symptomatic PAD have at least a 30% risk of death within 5 years rising to almost 50% within
10 years, resulting primarily from myocardial infarction or stroke [4]. Despite the major
health risks associated with PAD, it is generally not recognized by clinicians or the general
public in comparison with other cardiovascular diseases. However, asymptomatic individuals
also have higher risk of adverse cardiovascular events similar to those with symptomatic PAD
[6]. Many studies have shown that public awareness of PAD is much lower than that of other
diseases. It has been reported that awareness of PAD ranged from 20 to 36 %, whereas
awareness of other common diseases was more than 60 % in the same population [6-9]. Awareness
is important for patients and physicians, and the need for public awareness programs has been
highlighted [10, 11]. There is paucity of published literature on public awareness of PAD in
Asian countries. It is difficult to reduce the morbidity and mortality of untreated PAD
without adequate public awareness of PAD and its risk factors and consequences [7]. Insights
into public awareness of PAD will help in developing strategies for behavioral change
communication and health promotion. In this study we aimed to assess awareness of PAD among
adults in Hong Kong. The survey is designed to measure knowledge of factors that increase the
risk for PAD and the clinical risk consequences of having PAD. These data will provide useful
information to guide future local public cardiovascular educational efforts.
Description:
Peripheral arterial disease (PAD) is one of the most common cardiovascular diseases in
developed countries [1] and is an emerging problem in developing countries [2, 3]. The
prevalence of PAD in European population studies ranged from 3.6 to 9.2 % and 10-20 % in
those aged over 70 years [4]. In a recent meta-analysis, the prevalence of PAD in China
increased gradually by age until mid-60s, after which the increase accelerated. In males, the
prevalence of PAD ranged from 2.81% (95% CI = 1.77-4.43) in those aged 25-29 years to 21.95%
(95% CI = 15.39-30.31) in those 95-99 years old. In females, the PAD prevalence increased
from 3.84% (95% CI = 2.44-5.98) in those aged 25-29 years to 27.95% (95% CI = 20.14-37.37) in
those aged 95-99 years (3). Between 2000 and 2020, the total number of Chinese people with
PAD is expected to increase by 40% from 29.44 million in 2000 to 41.13 million in 2020.
In the early stages, PAD is mostly silent. With the progression of disease, it may manifest
as intermittent claudication, pain at rest, non
-healing ulcer and gangrene resulting in lower-extremity amputation [5]. PAD is a major cause
of disability, loss of employment, and lifestyle changes, and is a marker for systemic
atherosclerotic diseases. Patients with symptomatic PAD have at least a 30% risk of death
within 5 years rising to almost 50% within 10 years, resulting primarily from myocardial
infarction or stroke [4]. Despite the major health risks associated with PAD, it is generally
not recognized by clinicians or the general public in comparison with other cardiovascular
diseases. Most individuals with lower extremity PAD are asymptomatic and do not experience
recognizable ischemic symptoms until late in the disease progression. However, asymptomatic
individuals also have higher risk of adverse cardiovascular events similar to those with
symptomatic PAD [6]. Low awareness makes addressing the public health impact of PAD
challenging [7]. Many studies have shown that public awareness of PAD is much lower than that
of other diseases. It has been reported that awareness of PAD ranged from 20 to 36 %, whereas
awareness of other common diseases was more than 60 % in the same population [6-9]. Awareness
is important for patients and physicians, and the need for public awareness programs has been
highlighted [10, 11]. There is paucity of published literature on public awareness of PAD in
Asian countries. It is difficult to reduce the morbidity and mortality of untreated PAD
without adequate public awareness of PAD and its risk factors and consequences [7]. Insights
into public awareness of PAD will help in developing strategies for behavioral change
communication and health promotion. In this study we aimed to assess awareness of PAD among
adults in Hong Kong. The survey is designed to measure knowledge of factors that increase the
risk for PAD and the clinical risk consequences of having PAD. These data will provide useful
information to guide future local public cardiovascular educational efforts.
