Peripheral Arterial Disease Clinical Trial
Official title:
Pilot Study to Determine the Optimal Oscillometric-Based Technique for Measurement of Ankle Blood Pressures for the Ankle-brachial Index
Peripheral arterial disease (PAD) is a highly prevalent medical condition. Patients with PAD
are usually diagnosed on the basis of the ankle-brachial index. The ankle-brachial index is
the ratio of ankle pressure to arm pressure based on measurement of blood pressures in the
arms and legs using a Doppler device. The need for dedicated equipment and trained
personnel, along with the time required to perform the test, have been identified as
barriers to widespread implementation of ankle-brachial index screening. The use of
automated oscillometric devices for blood pressure measurement and determination of the
ankle-brachial index has been applied with variable success. It will be beneficial to
investigate a reliable oscillometric-based procedure that can accurately measure leg
pressures for the ankle-brachial index across the entire spectrum of PAD severity.
The purpose of this study is to determine the optimal oscillometric-based technique for
estimation of Doppler-derived systolic arm and ankle blood pressures for calculation of the
ankle-brachial index in patients with and without PAD.
Subjects with suspected arterial disease in the non-invasive lab will be enrolled. Arm,
ankle, and toe pressure measurements will be made in the supine position using Doppler,
oscillometric methods, and photoplethysmographic sensor. Arm and ankle pressures from a
subset of subjects will be obtained in both seated and supine positions. The ankle-brachial
index and toe-brachial index will be calculated.
n/a
Observational Model: Case-Only, Time Perspective: Prospective
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