Periodontal Intrabony Defects Clinical Trial
Official title:
A Comparative Clinical and Radiographic Evaluation of Demineralized Freeze Dried Bone Allograft (DFDBA) and Xenograft (Cerabone)TM With Decortication in the Treatment of Periodontal Intraosseous Defects
DFDBA is an allograft that possesses osteoconductive and osteoinductive properties. It has the potential for osteoinduction due to increased expression of bone morphogenetic protein (BMP).Cerabone™ has shown maximum resemblance to human bone with the potential to reconstruct bone defects. Decortication is performed as a part of guided bone regeneration (GBR) procedure as it enhances the healing process.Therefore a combination of decortication and bone graft when applied in periodontal intrabony defect would enhance the regeneration of periodontium.
There have been great strides in the management of periodontal intrabony defects, especially
with the use of bone graft materials. It is necessary to choose the most appropriate material
and procedure in order to obtain the desired regeneration. Among the bone grafts,
Demineralised freezed dried bone allograft (DFDBA) and xenografts have shown good results in
the management of intrabony defects. Recently, a novel bovine xenograft i.e., Cerabone™ has
shown maximum resemblance to human bone with the potential to reconstruct bone defects.
Decortication or intramarrow penetration of the bone has shown favourable results in guided
bone regeneration procedures. So the goal of the present study was to check the efficacy of
decortication with decalcified freeze dried bone allograft (DFDBA) and Cerabone™ bone grafts
and to compare the response between the bonegrafts placed following decortication using RVG
and CBCT, in intrabony defect.
The combination of decortication with bone grafts i.e., DFDBA and (Cerabone)TM can be an
added advantage in the treatment of intrabony defects. To the best of the investigators
knowledge no clinical trial reports this combination therapy in scientific literature. There
is need for further research in this area.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT02635529 -
DFDBA and Amniotic Membrane in the Treatment of Periodontal Osseous Defects
|
Phase 4 | |
| Not yet recruiting |
NCT05177198 -
Effects of Modified Minimally Invasive Surgical Technique With Clindamycin Augmented Platelet-rich Fibrin Versus Platelet-rich Fibrin Alone for Management of Periodontal Intrabony Defects.
|
N/A |