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Perinatal Stroke clinical trials

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NCT ID: NCT05346887 Active, not recruiting - Cerebral Palsy Clinical Trials

Home-based Early Intensive Hemiparesis Therapy: Engaging Nurture

HEIGHTEN
Start date: May 1, 2022
Phase: N/A
Study type: Interventional

The purpose of the study is to assess implementation and effectiveness of a caregiver-delivered rehabilitation intervention for infants and toddlers with cerebral palsy.

NCT ID: NCT05013736 Recruiting - Perinatal Stroke Clinical Trials

Baby Brain Recovery Study

Start date: July 26, 2022
Phase:
Study type: Observational

This study will be a longitudinal multiple-visit observational study, done to identify possible bioindicators of recovery and repair of motor corticospinal pathways which may be targeted by future interventions in infants with perinatal stroke. 65 participants will be recruited and complete 1 visit at time point 1 (0-2 months), and 2 visits at each timepoints 2-5 with windows of +- 4 weeks (3-6 months, 12 months, 18 months and 24 months). Visits will consist of Magnetic Resonance Imaging (MRI) assessment during the child's natural sleep, Transcranial Magnetic Stimulation (TMS), and Motor Behavioral Assessments.

NCT ID: NCT04233710 Recruiting - Clinical trials for Hemiplegic Cerebral Palsy

Robotic Rehabilitation and Brain Stimulation for Children With Hemiparetic Cerebral Palsy

RoboCP
Start date: March 25, 2019
Phase: Phase 2
Study type: Interventional

This study evaluates the use of robotic rehabilitation with and without transcranial direct current stimulation (tDCS) to improve motor performance in children with hemiparetic cerebral palsy. Half of the participants will receive robotic rehabilitation and half will receive robotic rehabilitation with tDCS. We hypothesize that tDCS may augment the robotic therapy and show greater improvements than robotic therapy alone.

NCT ID: NCT03910075 Recruiting - Hemiparesis Clinical Trials

Perinatal Arterial Stroke: A Multi-site RCT of Intensive Infant Rehabilitation (I-ACQUIRE)

I-ACQUIRE
Start date: October 10, 2019
Phase: Phase 3
Study type: Interventional

This is a Phase III clinical trial to compare the efficacy of two dosages of a new infant rehabilitation protocol - I-ACQUIRE - to usual and customary forms of infant rehabilitation in infants who experienced Perinatal Arterial Stroke (PAS).

NCT ID: NCT03672864 Active, not recruiting - Perinatal Stroke Clinical Trials

Parent Therapist Partnership to Provide Early, Intensive Exercise in Perinatal Stroke

Start date: February 15, 2019
Phase: N/A
Study type: Interventional

A prospective, single blind, parallel group, randomized control trial to determine if early, intensive lower extremity activity delivered by a physical therapist and a parent in partnership improves gross motor function more than usual care.

NCT ID: NCT03635775 Completed - Cerebral Palsy Clinical Trials

Single-session tDCS in Cerebral Palsy

Start date: May 1, 2018
Phase: N/A
Study type: Interventional

The goal of this study is to characterize individual responses to a single application of transcranial direct current stimulation (tDCS) in children with unilateral cerebral palsy (UCP), and to test which electrode configuration produces changes in brain excitability and motor function. Participants with UCP, ages 7-21 years, will be assigned to one of four tDCS groups. Using single-pulse transcranial magnetic stimulation, the investigators will assess cortical excitability before and at regular intervals up to 1 hour following tDCS. The knowledge gained from this study will advance the field through more targeted approaches of neuromodulatory techniques in this population and others, using individual characteristics to guide optimal treatment

NCT ID: NCT03216837 Completed - Clinical trials for Hemiplegic Cerebral Palsy

Stimulation for Perinatal Stroke Optimizing Recovery Trajectories

SPORT
Start date: July 21, 2017
Phase: Phase 2/Phase 3
Study type: Interventional

Perinatal stroke causes lifelong neurological disability and most hemiparetic cerebral palsy (CP). With morbidity spanning diverse aspects of a child's life and lasting for decades, global impact is large, including 10000 Canadian children. With pathophysiology poorly understood and prevention strategies non-existent, the burden of hemiparetic CP will persist. Limited treatments lead to loss of hope for children and families, necessitating exploration of new therapies. The investigators have evidence that the investigators have a durable new treatment for perinatal stroke, combining non-invasive neurostimulation and child-centred intensive rehabilitation. Via the CHILD-BRIGHT SPOR national network, the investigators will execute a multicentre trial to prove this treatment can improve function in children with perinatal stroke and hemiparetic CP. Using novel advanced technologies not available elsewhere in the world, the investigators will explore how developmental plasticity determines function and response to neuromodulation therapy. This patient oriented effort will advance personalized, precision medicine in pediatric neurorehabilitation to improve outcomes for disabled children and their families.

NCT ID: NCT03171818 Recruiting - Perinatal Stroke Clinical Trials

Darbepoetin for Ischemic Neonatal Stroke to Augment Regeneration

DINOSAUR
Start date: July 1, 2017
Phase: Phase 2
Study type: Interventional

The aim of the study is to perform a randomized double-blind placebo controlled prospective study in newborn infants with MRI confirmed Middle Cerebral Artery (MCA) Perinatal Arterial Ischemic Stroke (PAIS) with darbepoetin. It will be investigated whether intravenous administered darbepoetin can induce the formation of neuronal tissue and restore brain function in neonates who suffered from PAIS compared to placebo treated controls. The ultimate goal of this study is therefore to develop a therapy using erythropoiesis-stimulating agents (ESA) such as darbepoetin to reduce or even prevent lifelong consequences of PAIS-related brain injury in this group of term newborns.

NCT ID: NCT02170285 Completed - Cerebral Palsy Clinical Trials

Enhancing Motor Plasticity After Perinatal Stroke Using tDCS

tDCS
Start date: May 2014
Phase: Phase 2
Study type: Interventional

The purpose of this study is to test tDCS (transcranial direct current stimulation), a type of non-invasive brain stimulation, to determine whether it can improve motor function in children with perinatal stroke and hemiparesis. Children 6-18 years with imaging-confirmed perinatal stroke and functional motor impairment will be recruited. Children will be randomized (1:1) to receive sham or tDCS (20 minutes daily) during daily intensive, goal-directed motor learning therapy (90 minutes). Motor outcomes will be repeated at baseline, 1 week, and 2 months. Aim 1: Establish the ability of tDCS to safely enhance motor learning in children with perinatal stroke. Hypothesis 1: tDCS is safe and well tolerated in children. Hypothesis 2: Contralesional, cathodal tDCS increases motor functional gains measured by AHA at 2 months in children with perinatal stroke.

NCT ID: NCT02129491 Recruiting - Perinatal Stroke Clinical Trials

National Egyptian Network Pediatric Stroke and Hemiplegia Registry

Start date: January 2014
Phase: N/A
Study type: Observational [Patient Registry]

Our aim is to establish multi-center national Egyptian database of information about cerebrovascular stroke and hemiplegia in infants and children from 0 to 18 years of age.