Perimenopausal Disorder Clinical Trial
Official title:
Metabolic Effects of Muscle and Exercise Across Perimenopause
Starting in early-perimenopause, changes in systemic and tissue level metabolism result in an accelerated loss of muscle mass and an increase in body fat. Our preliminary work indicates that metabolic alterations, specifically a decrease in whole-body protein balance, increase in abdominal adiposity, and reduced metabolic flexibility during exercise is most evident in perimenopause. Exercise is a potent stimulator of skeletal muscle insulin sensitivity. High intensity interval training (HIIT) has been shown to be an effective exercise strategy to support cardiometabolic health in overweight and obese young women. Skeletal muscle is critical to maintaining metabolic health and functionality across the lifespan, and is considered the primary diver of whole-body insulin resistance.There is a significant decrease in muscle mass across the menopause transition, which is often exacerbated by a significant gain in fat mass and visceral fat. Protein consumption prior to HIIT has resulted in improvements in energy expenditure and fat oxidation in young women. The overarching objective of this study is to determine the metabolic response of HIIT compared to traditional aerobic exercise in early and late perimenopausal women. Aim 1 will examine the metabolic responses (glucose, insulin sensitivity, energy expenditure) of HIIT vs aerobic exercise, combined with pre-exercise carbohydrate or protein ingestion, in overweight/obese (BMI: 28-40 Kg/m^2) early and late perimenopausal women. Aim 2 will explore the impact of perimenopause on the fat oxidation and protein turnover before and after exercise. Lastly, aim 3 will explore the modulating effect of intramuscular fat on these metabolic outcomes.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05617287 -
An Exploratory Investigation of Dietary Supplementation and the Effect on Common Symptoms of Perimenopause and Menopause
|
N/A | |
| Recruiting |
NCT06192641 -
Melatonin Use in Patients With Climacterious Symptoms in the Perimenopause
|
Phase 2 | |
| Recruiting |
NCT05156814 -
Comparative Study to Evaluate the Efficacy and Safety of the Fixed-dose Combination of Estradiol / Dydrogesterone in Perimenopausal Women
|
Phase 4 | |
| Not yet recruiting |
NCT01481025 -
Efficacy and Safety for Cimicifuga/Hypericum Product
|
Phase 3 | |
| Completed |
NCT01475513 -
Oral Contraceptives, Insulin Resistance and Cardiovascular Risk Profile in Pre-Menopausal Women
|
Phase 4 | |
| Not yet recruiting |
NCT06419972 -
Multimodal Program for Climacteric Women
|
N/A | |
| Not yet recruiting |
NCT05922800 -
Effectiveness of Electro-Press Needle and Gamma-Oryzanol for Menopause-associated Hot Flashes
|
N/A | |
| Recruiting |
NCT03951194 -
Autologous Platelet Rich Plasma (PRP) Intra Ovarian Infusion in Perimenopausal Women
|
Phase 2/Phase 3 | |
| Not yet recruiting |
NCT04190927 -
A New Hormone Replacement Paradigm: Physiologic Restoration Study
|
Phase 4 | |
| Completed |
NCT03178695 -
Inovium Ovarian Rejuvenation Trials
|
Phase 1 | |
| Active, not recruiting |
NCT04444245 -
Ovarian Rejuvenation Using Platelet Rich Plasma (PRP) & Autologous Tissue Stromal Vascular Fraction (tSVF) and Cell Enriched tSVF
|
Phase 1 | |
| Terminated |
NCT03003949 -
The Menopause Transition: Estrogen Variability, Stress Reactivity and Mood
|
Phase 4 | |
| Completed |
NCT03740009 -
Effects of a Tissue Selective Estrogen Complex (TSEC) on Depression and the Neural Reward System in the Perimenopause"
|
Phase 4 | |
| Completed |
NCT03220672 -
Effectiveness of Assessment and Educational Intervention on Motor Control of the Pelvic Floor Muscle in Women
|
N/A | |
| Recruiting |
NCT06227858 -
Effects of a Standardised Saffron Extract Supplementation on Symptoms Associated With Perimenopause in Healthy Women
|
N/A | |
| Recruiting |
NCT04995107 -
Effectiveness of Electro-Press Needle for Menopause-associated Hot Flashes
|
N/A |