NCT04369170 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Alves CC, Muñoz F, Cantalapiedra A, Ramos I, Neves M, Blanco J
Marginal bone and soft tissue behavior following platform switching abutment connection/disconnection--a dog model study. Clin Oral Implants Res. 2015 Sep;26(9):983-91. doi: 10.1111/clr.12385. Epub 2014 Apr 16.
Belser UC, Schmid B, Higginbottom F, Buser D
Outcome analysis of implant restorations located in the anterior maxilla: a review of the recent literature. Int J Oral Maxillofac Implants. 2004;19 Suppl:30-42. Review.
Blanco J, Pico A, Caneiro L, Nóvoa L, Batalla P, Martín-Lancharro P
Effect of abutment height on interproximal implant bone level in the early healing: A randomized clinical trial. Clin Oral Implants Res. 2018 Jan;29(1):108-117. doi: 10.1111/clr.13108. Epub 2017 Dec 8. Erratum in: Clin Oral Implants Res. 2020 Oct;31(10):1037.
Nóvoa L, Batalla P, Caneiro L, Pico A, Liñares A, Blanco J
Influence of Abutment Height on Maintenance of Peri-implant Crestal Bone at Bone-Level Implants: A 3-Year Follow-up Study. Int J Periodontics Restorative Dent. 2017 Sep/Oct;37(5):721-727. doi: 10.11607/prd.2762.
Piao CM, Lee JE, Koak JY, Kim SK, Rhyu IC, Han CH, Herr Y, Heo SJ
Marginal bone loss around three different implant systems: radiographic evaluation after 1 year. J Oral Rehabil. 2009 Oct;36(10):748-54. doi: 10.1111/j.1365-2842.2009.01988.x. Epub 2009 Aug 20.
Tomasi C, Tessarolo F, Caola I, Wennström J, Nollo G, Berglundh T
Morphogenesis of peri-implant mucosa revisited: an experimental study in humans. Clin Oral Implants Res. 2014 Sep;25(9):997-1003. doi: 10.1111/clr.12223. Epub 2013 Jun 26.

Changes on the Interproximal Marginal Bone Level After CAD-CAM Designed Bridges Directly Placed on Bone-level Implants, or With Intermediate Abutments. A Randomized Clinical Trial

Details for clinical trial NCT04369170

Clinical trial NCT04369170 - References