Adjunctive Use of Dermal Matrix to Compensate Dimensional Changes in

Status Recruiting

Clinical Trial Summary

One critical element regarded to successfully resolve peri-implantitis is to efficiently decontaminate the contaminated implant surface. Mechanical, pharmacological and chemical strategies have been proposed to eliminate bacterial plaque and remnants from the implant surface. However, evidence has not demonstrated superiority of a given detoxification agent/strategy. Recently, the electrolytic approach has been indicated for the surgical detoxification in the management of peri-implantitis. For the electrolytic approach (EA) the implant has to be loaded negatively with a voltage and a maximum current of 600 mA. This is achieved by a device (GS1000, GalvoSurge Dental AG, Widnau, Switzerland) providing the voltage and pumping a sodium formiate solution through a spray-head, which has to be pressed into the implant by finger pressure to achieve an electrical contact. Another critical aspect in the management of peri-implantitis is related to the esthetic sequelae associated with disease resolution. Sanz-Martin et al. in a systematic review demonstrated that reconstructive therapy is less prone to exhibit mucosal recession when compared to resective therapy. Nonetheless, it seems to be unavoidable no matter the surgical intervention. Aiming at attenuating these changes, Schwarz et al. noted that the adjunctive use of connective tissue grafts may enhance the height of the mucosal level, which in turn may impact upon the esthetic outcome. Therefore, the research question is the following: What is the clinical, radiographic and 3D volumetric effectiveness of dermal matrix to improve the outcome of reconstructive therapy of peri-implantitis-related bone defects? The study is to be performed in two centers: Center of Implantology, Oral and Maxillofacial in Badajoz (Spain) and Clinical PerioCentrum Ortiz-Vigon in Bilbao (Spain)

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Peri-Implantitis

Clinical Trial Details

NCT number	NCT06398288
Study type	Interventional
Source	Center of Implantology, Oral and Maxillofacial Surgery, Badajoz, Spain
Contact	Mamen Tomé, DH
Phone	924203045
Email	mtome@periocicom.com
Status	Recruiting
Phase	N/A
Start date	March 1, 2024
Completion date	March 1, 2026

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05332327` - Comparison of the Accuracy of Different Periodontal Probes for Peri-implant Pocket Registration
Enrolling by invitation	`NCT06063876` - Experimental Peri-implant Mucositis on Implant Sites That Were Previously Treated With or Without Implantoplasty	N/A
Completed	`NCT04249024` - Peri-implantitis, Comparing Treatments 970 nm Laser and Mucosal Flap Surgery	N/A
Withdrawn	`NCT03624257` - Comparing Two Treatment Modalities of Peri-implantitis - Blue Laser (445 nm) and Conventional Flap Surgery	N/A
Completed	`NCT03018795` - Ozone Therapy as an Adjunct to the Surgical Treatment of Peri-implantitis	N/A
Completed	`NCT02375750` - Treatment of Peri-implantitis Lesions by Using Biomaterial	N/A
Completed	`NCT03157193` - Effect of Hyaluronic Acid on Perimplantitis	Phase 4
Enrolling by invitation	`NCT02575274` - Peri-Implantitis Surgical Treatment an RCT Study	Phase 2/Phase 3
Completed	`NCT04833569` - ICG-PDT, Periimplantitis, Diabetes Mellitus	Phase 1
Not yet recruiting	`NCT04337645` - Resective Surgical Treatment of Peri-implantitis.	N/A
Enrolling by invitation	`NCT06033859` - Incidence of Bleeding on Probing as an Indicator of Peri-Implant Disease Progression
Active, not recruiting	`NCT06390124` - Reconstructive Therapy of Peri-implantitis With PDGF-BB (Gem-21)	Phase 4
Enrolling by invitation	`NCT05675241` - Characterizing the Inflammation Around Dental Implants
Recruiting	`NCT04983758` - 20-year Implant Survival in Periodontally Healthy and Compromised Patients
Not yet recruiting	`NCT04323540` - Treatment of Peri-implantitis With or Without Simultaneous Soft Tissue Augmentation	N/A
Completed	`NCT04874467` - Influence of Keratinized Mucosa on Dental Implants With Mucositis	N/A
Completed	`NCT04769609` - Reconstructive Surgical Therapy of Peri-implantitis
Completed	`NCT05724706` - An Evaluation of Salivary Oxidant and Antioxidant Levels in Peri-implant Health and Disease
Completed	`NCT04559841` - Regenerative Surgical Treatment of Peri-implantitis Using Nanobone With or Without Simvastatin	N/A
Recruiting	`NCT05906810` - Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Peri-implantitis and Peri-implant Mucositis	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Adjunctive Use of Dermal Matrix to Compensate Dimensional Changes in the Reconstructive Therapy of Peri-implantitis

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms