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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT01621074
Other study ID # nbc
Secondary ID
Status Completed
Phase N/A
First received June 12, 2012
Last updated April 11, 2013
Start date October 2011
Est. completion date January 2013

Study information

Verified date April 2013
Source University of Zurich
Contact n/a
Is FDA regulated No
Health authority Switzerland: Ethikkommission
Study type Interventional

Clinical Trial Summary

During endurance exercise in the heavy and severe intensity domains, the rate at which metabolites that have been associated with the fatigue process (e.g. Pi, ADP, H, and extracellular K) accumulate increases. possibly leading to exercise cessation. Sodium bicarbonate, as a nutritional supplement, has gained attention over the past decades, because it might delay of offset fatigue. To date, there is a controversial discussion about which delivery mode (amount and frequency) might be best in optimizing endurance performance. Since the high ion load consequent to multiple ingestions might increase plasma volume, and consequently decrease bicarbonate concentrations, single acute ingestion could be more beneficial. However, in multi-day competitions or tournaments it might be necessary to use the supplement on a daily basis. Here, the investigators aim at investigating the effects of single dose or multiple dose (on five consecutive days) administration of bicarbonate vs. placebo increases endurance performance and acid-base homeostasis in trained male endurance athletes.


Recruitment information / eligibility

Status Completed
Enrollment 12
Est. completion date January 2013
Est. primary completion date August 2012
Accepts healthy volunteers No
Gender Male
Age group 18 Years to 45 Years
Eligibility Inclusion criteria: - male

- no cold or temperature at beginning or during the study

- between 18 and 45 years of age

- active in endurance sports (3 to 5 times per week a moderate to hart training)

- non-smoker

- no known cardiovascular or orthopedic problems

- no known limitations of kidney function

- no bearer of a cardiac pacemaker

- no medications with direct influence on the measurements. The whole intake of medicaments has to be declared in the health questionnaire by the participant.

- requirements of the health questionnaire fulfilled

Exclusion criteria: - female

- male and age under 18 or over 45 years

- cold or temperature at the beginning or during the study

- untrained (less than 3 moderate trainings per week)

- smoker

- cardiovascular or orthopedic problems

- limitations of the kidney function

- bearer of a cardiac pacemaker

- medication with direct influence on the measurements. The whole intake of medicaments has to be declared in the health questionnaire by the participant.

- requirements of the health questionnaire not fulfilled

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Outcomes Assessor)


Related Conditions & MeSH terms


Intervention

Dietary Supplement:
Sodium bicarbonate
Ergogenic effect
Placebo
Placebo effect

Locations

Country Name City State
Switzerland University Hospital Zurich, Division of Neurology Zurich ZH

Sponsors (2)

Lead Sponsor Collaborator
University of Zurich Swiss Federal Institute of Technology

Country where clinical trial is conducted

Switzerland, 

Outcome

Type Measure Description Time frame Safety issue
Primary Time-to-exhaustion 5 weeks No
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