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Peptic Ulcer clinical trials

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NCT ID: NCT06393907 Recruiting - Clinical trials for Gastroduodenal Ulcer

Hemostatic Forceps vs. Bipolar Electrocautery Probes for High-Risk Bleeding Gastroduodenal Ulcers

Start date: March 26, 2024
Phase: N/A
Study type: Interventional

A randomized controlled trial to evaluate the efficacy of hemostatic forceps and bipolar electrocautery probes in patient with high risk bleeding gastroduodenal ulcers.

NCT ID: NCT06168084 Recruiting - Clinical trials for Gastritis Dyspepsia Helicobacter Pylori Infection Gastric Cancer Peptic Ulcer

Helicobacter Rescue Therapy With Vonorazon and Amoxicillin Dual Therapy Versus Bismuth-containing Quadruple Therapy

Start date: June 6, 2023
Phase: Phase 4
Study type: Interventional

This study aims at evaluating efficacy and safety of Vonorazon and amoxicillin dual therapy versus bismuth-containing quadruple Therapy(bismuth#esomeprazole#tetracycline and furazolidone) in H. pylori rescue therapy. It is hypothesized that Vonorazon and amoxicillin dual therapy is non-inferior to bismuth-containing quadruple Therapy. Patients with confirmed failure of H. pylori eradication will be randomized to one of the treatments described above. At week 6 follow-up visits, a urea breath test#rapid urease test or helicobacter pylori stool antigen test will be performed to confirm eradication.

NCT ID: NCT06084741 Recruiting - Clinical trials for Peptic Ulcer Perforations

Omitting Drains After Repair of Peptic Ulcer Perforations

Start date: March 25, 2023
Phase: N/A
Study type: Interventional

. This study aimed to evaluate ERAS application outcomes via omitting the intraabdominal drains compared to regular using of the drains in patients undergoing perforated duodenal ulcer repairs in emergency abdominal surgeries.

NCT ID: NCT06042933 Recruiting - Clinical trials for Peptic Ulcer Perforation

Early Oral Feeding Versus Traditional Delayed Oral Feeding Post-perforated Peptic Ulcer Repair

Start date: March 2, 2023
Phase: N/A
Study type: Interventional

This study aims to evaluate safety and benefits of early oral feeding compared to traditional delayed oral feeding in patients undergoing perforated peptic ulcer repairs. Study population & Sample size :(

NCT ID: NCT05799105 Recruiting - Marginal Ulcer Clinical Trials

OPEN Versus InTact Capsule Proton Pump Inhibitors for the Treatment of Marginal Ulcers

OPEN-IT
Start date: March 14, 2023
Phase: Phase 4
Study type: Interventional

The goal of this clinical trial is to identify the most effective way to take acid-blocking medications to treat stomach ulcers in patients who have undergone gastric bypass surgery. The main questions it aims to answer are: - is taking an acid-blocking medication by opening the capsule and only taking the contents of the capsule (open-capsule) more or less effective than taking the capsule as a whole (intact-capsule) for treating ulcers in patients who have a history of gastric bypass surgery? - does taking the open versus intact medication decrease the number of procedures and complications from untreated ulcers? Participants with ulcers will be instructed to take acid-blocking medications (called proton-pump inhibitors) either by opening the capsule and taking only the contents or by taking the capsule whole. These medications are the gold standard for treatment of stomach ulcers. Participants will be asked to undergo an upper endoscopy (EGD) every 3 months to monitor the healing of the ulcers. Researchers will compare how quickly the ulcers heal depending on which way the medications are taken (opened up or as a whole).

NCT ID: NCT05742568 Recruiting - Gastric Cancer Clinical Trials

Effects of High-dose Dual Therapy and Bismuth Quadruple Therapy for Helicobacter Pylori Eradication on Intestinal Microecology

Start date: December 1, 2022
Phase: Phase 4
Study type: Interventional

This study was conducted to investigate the effects of high-dose diphtherapy and bismuth quadruple therapy on H. pylori eradication on intestinal microecology, to clarify the changes in intestinal microbiota diversity and structure before and after the two treatment regimens, and to explore the relationship between different treatment regimens and intestinal microbiota dysbiosis; to further guide the safety and drug resistance of H. pylori eradication by the two treatment regimens. The expected results are to observe the changes of intestinal microbiota diversity and structure before and after treatment with the two treatment regimens.

NCT ID: NCT05670457 Recruiting - Clinical trials for Non-bleeding Peptic Ulcer

Diosmin as Adjuvant Therapy in Treatment of Non-bleeding Peptic Ulcer

Start date: June 30, 2022
Phase: Phase 3
Study type: Interventional

The aim of the study is to evaluate the safety and efficacy of diosmin as adjuvant therapy in treatment of non-bleeding peptic ulcer patients.

NCT ID: NCT05582174 Recruiting - Upper GI Bleeding Clinical Trials

PPI Infusion Versus Oral Acid Pump Inhibitors for Bleeding Peptic Ulcers

Start date: May 18, 2023
Phase: Phase 4
Study type: Interventional

Vonoprazan (VPZ), an oral potassium-competitive acid blocker (P-CAB) has emerged as an alternative potent acid-suppressant.It has a faster onset of action in 1 day (3-5 days in PPI), and is more stable in acidic condition than PPI. While many studies compared Vonoprazan against PPI in the treatment of reflux oesophagitis, H. Pylori eradication, and gastric ulcers; thus far, there is a paucity of data on use of Vonoprazan on bleeding peptic ulcers. We perform a multicenter randomized controlled trial (RCT) to compare the efficacy of oral Vonoprazan against standard high dose PPI therapy in bleeding peptic ulcers that had received successful endoscopic haemostasis We hypothesize that in patients with bleeding peptic ulcers, the use of acid pump inhibitors Vonoprazan would not be inferior to standard treatment of a bolus plus high dose PPI intravenous infusion at preventing recurrent bleeding after endoscopic haemostasis.

NCT ID: NCT05551832 Recruiting - Clinical trials for BIle Duct Diseae(Benign/Malignancy)

Prevalence of Marginal Ulcer After PPPD and Preventive Effect of Proton Pump Inhibitor in Korea: A Prospective Multicenter Study

Start date: October 10, 2022
Phase: Phase 3
Study type: Interventional

This research is to determine which medication, Esmesol (PPI) or Placebo works best at reducing the chance that a patient will get an marginal ulcer after pancreaticoduodenectomy.

NCT ID: NCT05368233 Recruiting - Emergencies Clinical Trials

Impact of Abdominal Drains on the ERAS Pathway in Peptic Perforation

TUBELESS
Start date: June 15, 2022
Phase: N/A
Study type: Interventional

This study plans to assess the effect of placement of abdominal drains on the outcomes of ERAS (Enhanced recovery after surgery) protocol in the perioperative management of peptic perforation. In the study arm ERAS protocol will be implemented avoiding use of abdominal drain. In the control arm abdominal drains will be placed in the early post operative period while using the ERAS protocol. The effect of drains on duration of post operative stay and other return to physiological parameter like onset of ambulation, oral intake, passing flatus and feces etc. will be studied. The investigators hypothesize that the non-placement of abdominal drain postoperatively will not have worse outcomes than in cases where it is used postoperatively, in terms of length of hospital stay. .