Pemphigus Clinical Trial
Official title:
Role of Proteasomes in a Dermatological Autoimmune Disease: Bullous Pemphigoid
The primary objective of this study is to describe and compare plasmatic anti-proteasome auto-antibody concentrations among three distinct groups: (1) patients suffering from bullous pemphigoide; (2) patients suffering from other dermatological auto-immune diseases; (3) an elderly control group.
The secondary objectives of this study are:
To compare the following parameters between the 3 groups:
- plasmatic proteasome concentrations
- plasmatic proteasome proteolytic activity
To explore the potential relationships between:
- plasmatic proteasome concentrations
- plasmatic proteasome proteolytic activity
- plasmatic anti-proteasome auto-antibody concentrations
- measures of disease severity for dermatological auto-immune diseases
To characterize plasmatic anti-proteasome auto-antibodies in patients suffering from bullous
pemphigoide and other dermatological auto-immune diseases (other bullous auto immune
diseases: pemphigus, cutaneous lupus, ...).
To characterize the expression and the activity of proteasomes in skin samples, in plasma and
in circulating mononuclear cells in patients with bullous pemphigoide.
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