Pelvic Pain Clinical Trial
Official title:
Intravesical Liposomes for Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS)
Interstitial cystitis/painful bladder syndrome (IC/PBS) is a poorly understood chronic
disorder of unknown etiology consisting of irritative bladder symptoms and pelvic pain that
dramatically affects quality of life.
Preclinical study data (obtained by using an IC/PBS model in Sprague-Dawley female rats)
have demonstrated normalization of urinary frequency indicating that LP may be a potent
protectant of the bladder mucosa against inflammation and irritation. Intravesical LP has so
far demonstrated an excellent safety profile and minimal toxicity at concentrations of 2
mg/ml. Thus, we hypothesize that intravesical instillation of LP may form a molecular film
on bladder ulcer surfaces in patients with IC and provide a safe, effective, and minimally
invasive treatment option to alleviating symptoms.
Liposomes (LP), the treatment article in this proposal, were discovered in the process of exploring a "control" compound when measuring the efficacy of liposomally encapsulated capsaicin for the intravesical treatment of interstitial cystitis. Liposomes are lipid vesicles composed of concentric phospholipid bilayers, which enclose an aqueous interior. Liposomes have the ability to form a molecular film on cell and tissue surfaces and are currently being tested as possible therapeutic agents to promote wound healing. Application of liposomes at the wound surface provides a moist protective film over the wound and augments wound healing without chronic inflammatory reactions in the neodermal layer. ;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03740932 -
Effect of Biomechanical Alignment and Jaw on Women With Pelvic Pain
|
||
| Completed |
NCT04077801 -
Effect Of Chronic Pelvic Pain on Lumbopelvic Alignment And TemproMandibular Joint Kinematics in Women
|
||
| Completed |
NCT04081532 -
The Effectiveness of Laparoscopic Treatment of Superficial Endometriosis for Managing Chronic Pelvic Pain
|
N/A | |
| Recruiting |
NCT06101303 -
Endometriosis Pain
|
||
| Recruiting |
NCT03868137 -
Multi-dose Ibuprofen Prophylaxis for IUD-insertion
|
N/A | |
| Suspended |
NCT04069572 -
Vibratory Stimulation for the Treatment of Chronic Pain
|
N/A | |
| Completed |
NCT02923245 -
POCUS Assessment of Bladder Fullness for Girls Awaiting Radiology-Performed Transabdominal Pelvic Ultrasound
|
N/A | |
| Completed |
NCT02547857 -
Transvaginal Pelvic Ultrasound in the ED
|
N/A | |
| Completed |
NCT01938092 -
Vaginal Diazepam for the Treatment of Female Pelvic Pain
|
Phase 2 | |
| Completed |
NCT01421641 -
Tenaculum Pain Control Study
|
Phase 4 | |
| Completed |
NCT00034047 -
Endometriosis : Traditional Medicine vs Hormone Therapy
|
Phase 1/Phase 2 | |
| Completed |
NCT05368155 -
Chronic Pelvic Pain and Education Skills Training for Women Veterans
|
N/A | |
| Completed |
NCT04179149 -
Enriched Environments in Endometriosis
|
N/A | |
| Not yet recruiting |
NCT05530681 -
Correlation Pelvic Floor Function and Ultrasound Findings One Year After Childbirth
|
N/A | |
| Completed |
NCT04077775 -
Temporomandibular Joint Kinematics Changes in Pregnant Women: A Case-control Study
|
||
| Completed |
NCT03715777 -
Electromyographic Study for the Help and Guidance of BoNTA Administration in the Treatment of Chronic Pelvic Floor Pain
|
Phase 3 | |
| Recruiting |
NCT05926752 -
Photobiomodulation for Myofascial Pelvic Pain
|
N/A | |
| Completed |
NCT02588885 -
Restoring Emotional, Sexual, and Physical Empowerment Through CBT & Trauma-sensitive Care: A Chronic Pelvic Pain Intervention
|
N/A | |
| Completed |
NCT02261740 -
Program to Overcome Pelvic Pain With Yoga
|
N/A | |
| Completed |
NCT02259712 -
Effectiveness of Hypopressive Exercises Versus Pelvic-perineal Physiotherapy
|
N/A |