The Effect of Nitroprusside on Intrauterine Device (IUD) Insertion

Status Completed

Clinical Trial Summary

Increasing accessibility of long-acting reversible contraceptive methods, like intrauterine devices (IUDs), is an important strategy to reduce the risk of unintended pregnancy. Unfortunately, fear of IUD insertion in women who have not had children is common among health care providers and women alike, and this limits IUD use. To increase acceptance of this highly effective contraceptive, there is need to investigate novel, low cost, easily applied and accessible techniques to improve the insertion experience. This is a pilot study to evaluate the efficacy and tolerability of nitroprusside gel applied intracervically as an intervention to improve the IUD insertion experience for both patient and provider.

Clinical Trial Description

Subjects who are have already scheduled an IUD insertion will be asked to join this study assessing whether or not nitroprusside gel helps with IUD insertion process. Only healthy, nulliparous women between the ages of 18 and 45 will be recruited. Nulliparous women report much more pain associated with IUD insertion than parous women so the possibility of being able to measure the effect of nitroprusside vs placebo is more likely. The primary outcome, pain with IUD insertion, and the secondary outcomes, such as satisfaction and provider ease of IUD insertion, will be compared between the study groups as well. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01248091
Study type	Interventional
Source	Oregon Health and Science University
Contact
Status	Completed
Phase	N/A
Start date	December 2010
Completion date	July 2011

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04077801` - Effect Of Chronic Pelvic Pain on Lumbopelvic Alignment And TemproMandibular Joint Kinematics in Women
Completed	`NCT03740932` - Effect of Biomechanical Alignment and Jaw on Women With Pelvic Pain
Completed	`NCT04081532` - The Effectiveness of Laparoscopic Treatment of Superficial Endometriosis for Managing Chronic Pelvic Pain	N/A
Recruiting	`NCT06101303` - Endometriosis Pain
Recruiting	`NCT03868137` - Multi-dose Ibuprofen Prophylaxis for IUD-insertion	N/A
Suspended	`NCT04069572` - Vibratory Stimulation for the Treatment of Chronic Pain	N/A
Completed	`NCT02923245` - POCUS Assessment of Bladder Fullness for Girls Awaiting Radiology-Performed Transabdominal Pelvic Ultrasound	N/A
Completed	`NCT02547857` - Transvaginal Pelvic Ultrasound in the ED	N/A
Completed	`NCT01938092` - Vaginal Diazepam for the Treatment of Female Pelvic Pain	Phase 2
Active, not recruiting	`NCT01731470` - Intravesical Liposomes for Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS)	N/A
Completed	`NCT01421641` - Tenaculum Pain Control Study	Phase 4
Completed	`NCT00034047` - Endometriosis : Traditional Medicine vs Hormone Therapy	Phase 1/Phase 2
Completed	`NCT05368155` - Chronic Pelvic Pain and Education Skills Training for Women Veterans	N/A
Completed	`NCT04179149` - Enriched Environments in Endometriosis	N/A
Not yet recruiting	`NCT05530681` - Correlation Pelvic Floor Function and Ultrasound Findings One Year After Childbirth	N/A
Completed	`NCT04077775` - Temporomandibular Joint Kinematics Changes in Pregnant Women: A Case-control Study
Completed	`NCT03715777` - Electromyographic Study for the Help and Guidance of BoNTA Administration in the Treatment of Chronic Pelvic Floor Pain	Phase 3
Recruiting	`NCT05926752` - Photobiomodulation for Myofascial Pelvic Pain	N/A
Completed	`NCT02588885` - Restoring Emotional, Sexual, and Physical Empowerment Through CBT & Trauma-sensitive Care: A Chronic Pelvic Pain Intervention	N/A
Completed	`NCT02261740` - Program to Overcome Pelvic Pain With Yoga	N/A