Comparison of Two Intervention in Children With Functional Constipation

Pediatric Clinical Trial

Official title:

Comparison of Therapeutic Motor Control Interventions and Conventional Treatment in Children With Functional Constipation

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05371678
• Other study ID #: AIBU-FTR-BI
• Status: Recruiting
• Phase: N/A
• Start date: April 18, 2022
• Est. completion date: September 2023

Study information

• Verified date: May 2022
• Source: Abant Izzet Baysal University
• Contact: Büsra Inal, M.Sc.
• Phone: 905323903578
• Email: inalbusra[@]yahoo.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study; to compare the effects of therapeutic motor control interventions and conventional treatment in children with functional constipation on symptoms, spinal posture and mobility and trunk muscles endurance.

Description:

Constipation is a very common problem in children. The pathophysiology of pediatric constipation is multifactorial and not fully understood. Constipation is a problem characterized by infrequent, difficult, often painful defecation and involuntary leakage of stool. It has been reported in the literature that the prevalence of constipation in children is 30%. It has been determined that approximately 96% of children with constipation have functional constipation.

It has been shown in the literature that children with functional constipation had a protrusion in the abdomen compared to healthy children, and their ability to actively relax their trunks decreased. Thus, it has been suggested that children with functional constipation may have reduced trunk muscle and/or endurance or muscle control. As a result of this study, they recommend that the treatment of these children should focus on awareness and education about trunk muscles, defecation and correction of sitting position.

According to the Cochrane systematic review published in 2016, physiotherapy and rehabilitation methods in bladder and bowel dysfunction are generally divided into two as education and specific methods. Specific methods are therapeutic motor control methods, manual therapy techniques (abdominal classical massage) and electrotherapy.

The use of therapeutic motor control methods in the treatment of constipation in children is quite new, and there is a need for innovative studies in this field in the literature.

The conventional treatment in children with functional constipation is education and laxatives.

In the light of this information, in this study considered that therapeutic motor control methods (core stabilization exercises, Electromyographic-Biofeedback therapy and breathing exercises) may have an effect on the symptoms of children with constipation. The primary aim of this study is to compare the effectiveness of therapeutic motor control methods and conventional treatment on constipation symptoms in children with functional constipation.

Children will be divided into 2 groups with the randomization program. Educational training, breathing exercises, dietary recommendations, core stabilization exercises and Electromyographic-Biofeedback therapy will be applied to the first group. The 2nd group is the control group and this group will receive routine treatment. Group 2 will receive laxative therapy by a specialist doctor along with educational training, dietary recommendations.

The duration of treatment will be 8 weeks. All children will be evaluated before and after 8 weeks of treatment. The first group will be treated by a physiotherapist in 2 sessions a week for 8 weeks. Each session will take approximately 60 minutes. Group 2 will receive routine treatment for 8 weeks.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 36
• Est. completion date: September 2023
• Est. primary completion date: April 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 4 Years to 18 Years

Eligibility

Inclusion Criteria:

• Voluntary participation in the research

• Fulfill the diagnostic criteria for functional constipation (Rome IV)

Exclusion Criteria:

• Having neurological diseases

• Having chronic diseases

• Having previous orthopedic surgery or trauma

• Presence of organic pathology underlying constipation.

Related Conditions & MeSH terms

• Constipation
• Constipation - Functional
• Pediatric

Intervention

Other:
• Therapeutic motor control interventions
Treatment duration will be 8 weeks, two sessions a week. Each session will take approximately 60 minutes. This intervention includes education, dietary advices, core stabilization exercises and pelvic floor muscle training with surface Electromyographic-Biofeedback. In the education will be taught to the child and their parents in the first session. Dietary advices will be given by specialist dietitian. Core stabilization exercises will be performed 2 days a week with a physiotherapist and the session will be approximately 50 minutes. Diaphragmatic breathing will be taught to children in breathing exercises. The pelvic floor muscles exercises will be do by surface Electromyographic-Biofeedback. The Electromyographic-Biofeedback teaches the child how to relax the external anal sphincters with visual and auditory feedback techniques.The child will learn to relax the pelvic floor muscles during defecation by monitoring the recorded electromyographic activity.
• Conventional treatment
Treatment duration will be 8 weeks. This intervention includes education, dietary advices and laxative therapy. In the education will be taught to the child and their parents in the first session. Dietary advices will be given by specialist dietitian. Laxative therapy will be adjusted at different doses according to the child's age and weight. Laxative therapy will be administered to children by a specialist doctor.

Locations

Country	Name	City	State
Turkey	Faculty of Health Sciences Bolu Abant Izzet Baysal University	Bolu

Sponsors (1)

Lead Sponsor	Collaborator
Abant Izzet Baysal University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Vancouver Non-Neurogenic Lower Urinary Tract Dysfunction/Dysfunctional Elimination Syndrome Questionnaire- symptom assessment	Vancouver Non-Neurogenic Lower Urinary Tract Dysfunction/Dysfunctional Elimination Syndrome Questionnaire was developed in 2009. The questionnaire consists of 14-item. Each question is 5-Likert type, and the last question is not added to the scoring. The total score ranges from 0 to 52 and increasing score means an increase in symptom severity.	Eight weeks
Primary	7-day bowel diary (symptom assessment)	The bowel histories of the children (frequency of defecation, fecal incontinence, feeling urgency defecations...) will be evaluated with a 1-week bowel diary.	Eight weeks
Secondary	Spinal Posture	Spinal posture evaluations of children will be perform with the Spinal Mouse, which is a computer-assisted and non-invasive electromechanical device. Spinal posture evaluations will be perform in standing upright position. After taking the evaluation position, the Spinal Mouse device will be moved by sliding down through all spinal processes starting from the C7 spinal process to the S3 spinal process. Relevant parameters in standing upright position [thoracic curvature angle (from T1 to T12), lumbar curvature angle (from T12 to S1), sacrum-hip angle (difference between the sacral angle and the vertical), inclination angle (angle formed by the vertical and a line joining C7 to sacrum)] were recorded by the Spinal Mouse device via bluetooth and will be analyzed.	Eight weeks
Secondary	Spinal Mobility	Spinal mobility evaluations of children will be perform with the Spinal Mouse, which is a computer-assisted and non-invasive electromechanical device. Spinal posture and mobility evaluations will be perform in 3 different positions: standing upright, maximum flexion and maximum extension. After taking the evaluation position, the Spinal Mouse device will be moved by sliding down through all spinal processes starting from the C7 spinal process to the S3 spinal process. Relevant parameters in standing upright position [thoracic curvature angle (from T1 to T12), lumbar curvature angle (from T12 to S1), sacrum-hip angle (difference between the sacral angle and the vertical), inclination angle (angle formed by the vertical and a line joining C7 to sacrum)] were recorded by the Spinal Mouse device via bluetooth and will be analyzed.	Eight weeks
Secondary	Trunk flexor muscle endurance test	In the trunk flexor endurance test, the child is in a long sitting position on the treatment bed. At this time, the trunk is supported by a wedge in 60° flexion and knees and hips flexed 90°, arms crossed in front of the chest. The feet are fixed to the bed with a belt. The wedge supporting the trunk is retracted by 10 cm and the child tries to maintain his position as much as possible. The test is terminated when the child's trunk touches the wedge or the test time exceeds 300 seconds.	Eight weeks
Secondary	Trunk extensor muscle endurance test	In the trunk extensor endurance test, the child lies in the prone position with his hips at the edge of the treatment bed. Pelvis, hips and knees are fixed to the treatment bed with belts. The child tries to keep it in a horizontal body position as much as possible by crossing his arms in front of his body. This test is terminated when the child cannot maintain the horizontal position or the test time exceeds 300 seconds.	Eight weeks
Secondary	Trunk right lateral bridge test	In the right bridge trunk endurance test, the test begins when the child's knees are extended and the upper foot is placed in front of the lower foot in the right side lying position. The child's upper arm is holding the other shoulder. The child carries his/her body weight with his/her lower elbow and feet, and he/she should keep his/her torso in a straight line as much as possible throughout the test. The test is terminated when this side lying position is disturbed or the hip touches the treatment bed or the test time exceeds 300 seconds.	Eight weeks
Secondary	Trunk left lateral bridge test	In the left bridge trunk endurance test, the test begins when the child's knees are extended and the child's upper foot is placed in front of the lower foot in the left side lying position. The child's upper arm is holding the other shoulder. The child carries his/her body weight with his/her lower elbow and feet, and he/she should keep his/her torso in a straight line as much as possible throughout the test. The test is terminated when this side lying position is disturbed or the hip touches the treatment bed or the test time exceeds 300 seconds.	Eight weeks
Secondary	Physical activity level (pedometer)	Physical activity level will be assessed by pedometer. Step counts of children will be recorded with the pedometer for a total of 4 days, 2 days on weekdays and 2 days on weekends. The pedometer will be fixed on the hips of the children.	Eight weeks
Secondary	Physical activity level (questionnaire)	Physical activity level will be assessed by questionnaire.The physical activity questionnaire for children (PAQ-C) will assess physical activity the ages of 8-14 years.The total score of the PAQ-C consists of the first 9 items. A score of 1 means low level of physical activity, while a score of 5 means high physical activity. PAQ for Adolescents (PAQ-A) is a questionnaire designed to evaluate the physical activity of students aged 14-20 attending secondary education during the last 7 days of the school term.A score of '1' corresponds to low-intensity physical activity and a score of '5' corresponds to high-intensity physical activity, but the last question is not included in the scoring. The total score is obtained by calculating the average score of all questions.	Eight weeks
Secondary	Evaluation of subjective perception of improvement	The Global Perceived Impact scale will be used to evaluate children after treatment (week 8). Children will be asked to rate the extent to which their complaints have improved on a 4-item Likert-type scale. Description of scores; '1' would be 'worsened', '2' would be 'unchanged', '3' would be 'better', '4' would be 'completely healed'	Eight weeks
Secondary	Evaluation of compliance with lifestyle changes	After the treatment (8th week), the degree of compliance of the children with the recommendations for lifestyle changes will be evaluated with the Visual Analog Scale. Children will be asked to mark the point that best describes them on a vertical line 10 cm long. The distance of the marked point to the '0' point will be measured with a ruler and recorded in cm. On this scale, the '0' point will be defined as 'Never (0%) I Have Not Complied' and the '10' point will be defined as 'I Have Fully (100%) Compliance'.	Eight weeks
Secondary	Evaluation of compliance with breathing exercises	After the treatment, the degree of compliance of the children in Group 1 towards breathing exercises will be evaluated with the Visual Analog Scale. Children will be asked to mark the point that best describes them on a vertical line 10 cm long. The distance of the marked point to the '0' point will be measured with a ruler and recorded in cm. On this scale, the '0' point will be defined as 'Never (0%) I Have Not Complied' and the '10' point will be defined as 'I Have Fully (100%) Compliance'.	Eight weeks