Pediatric Surgery Clinical Trial
Official title:
A Randomised Controlled Trial Comparing Pre-oxygenation Strategies With High-flow Humidified Nasal Oxygenation Versus Apnoeic Facemask Oxygenation During Rapid Sequence Induction in Children Aged Less Then 11 Years
This randomised study aims to compare the utilization of high-flow humidified nasal oxygenation (HFNO) with standard care, using apnoeic facemask oxygenation, during rapid sequence induction (RSI) of anesthesia in young children. 170 children aged less then 11 years, admitted to the operating room for surgery and with a medical indication of a RSI of anesthesia will be recruited in one university hospital (Necker-Enfants-Malades in Paris). Children will be randomly assigned into two groups: the control group will benefit of standard care and the HFNO group will receive heated and humidified oxygen through a nasal cannula device during pre-oxygenation and apnoea time prior to tracheal intubation. HFNO has been evaluated and showed benefits in rapid sequence induction of anesthesia in adults and prolonged apnea time before desaturation in children. To the investigators' knowledge the potential benefit of HFNO during RSI in young children remain to be evaluated.
Hypoxic events during rapid sequence induction (RSI) in children remain more frequent than during standard induction. Although the exact incidence is difficult to appreciate. However the deleterious consequences of hypoxemia during tracheal intubation procedures are well known. HFNO is an effective technique to supplement oxygen including during apnoea. Studies in children have shown benefits both during breathing and apneic situation. A monocentric controlled randomized study including children, aged less then 11 years, will be conducted in order to assess the potential benefits of this technique during RSI. The rate of successful tracheal intubation without oxygen desaturation is the primary outcome. Children will be randomly assigned into two groups: - The control group will benefit of standard RSI. Pre-oxygenation will be given through facemask with 100% oxygen during 2 minutes, with a flow of 6 to 8 L.min-1 depending on the age of the child. No oxygen will be delivered during laryngoscopy. - The HFNO group will be given 2 L.Kg-1.min-1 of humidified and heated 100% O2 through a nasal cannula during a 2 minutes pre-oxygenation and then throughout laryngoscopy. Adverse events will be recorded and follow-up continued until discharge from the post anesthesia care unit (PACU). ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Enrolling by invitation |
NCT04709315 -
Rapid Sequence Induction: Succinyl Choline vs Rocuronium After Pretreatment With Dexmedetomidine
|
Phase 3 | |
Recruiting |
NCT05775029 -
RSI Observation Follow-up
|
||
Terminated |
NCT05384665 -
Impact of Opioids on Heart Rate During Rapid Sequence Intubation
|
N/A | |
Completed |
NCT04312425 -
Classic and Modified Rapid Sequence Induction for Prevention of Gastric Content Regurgitation
|
||
Completed |
NCT02751684 -
EUROpE-RSI (EURopean Online Evaluation RSI Study)
|
||
Completed |
NCT04926337 -
Preoxygenation With High-flow Nasal Oxygen in Adult Trauma Patients During Rapid Sequence Induction Anaesthesia
|
||
Not yet recruiting |
NCT05067829 -
Rapid Sequence Intubation With Rocuronium in Elderly Patients
|
N/A | |
Completed |
NCT03694860 -
Rapid Sequence Induction EU: Electronic Survey (RSIEU)
|
||
Completed |
NCT02985970 -
Rapid Sequence Induction Czech Republic: Survey
|
N/A |