Pediatric Cancer Clinical Trial
Official title:
Vascular Endothelial Inflammation and Dysfunction in Pediatric Long-term Cancer Survivors
Verified date | September 2015 |
Source | University of Miami |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Institutional Review Board |
Study type | Interventional |
Survivors of childhood cancer have an increased risk of death from cardiovascular disease due to both the therapies they received while undergoing treatment and diet and lifestyle factors. The nature of cardiovascular risk and the interaction between treatment affects and cardiovascular risk factors is unknown. We propose to study vascular inflammatory markers as well as measure of blood vessel stiffness (both of which are predictive of early heart disease) in 100 pediatric cancer survivors and 100 control children. Characterization of vascular inflammation and stiffness in long-term survivors will allow for the development of future interventions to decrease inflammation through both pharmacologic and lifestyle modifications.
Status | Completed |
Enrollment | 6 |
Est. completion date | August 2015 |
Est. primary completion date | August 2015 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 6 Years to 30 Years |
Eligibility |
Inclusion Criteria: - 6-30 years of age - 2 years from the completion of therapy for cancer - free of active disease Exclusion Criteria: - <6 or > 30 years of age - current cancer treatment or inside of 2 years post treatment - Active disease/infection |
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Country | Name | City | State |
---|---|---|---|
United States | University of Miami, MIller School of Medicine | Miami | Florida |
Lead Sponsor | Collaborator |
---|---|
University of Miami |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Vascular Inflammation | All study procedures to assess vascular inflammation will be assessed through specimen sample collection and through procedures such as (echocardiograph) | single time point at initial visit | No |
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