PDA Clinical Trial
Official title:
Paracetamol (Acetaminophen) for Closure of PDA in Preterm Infants
There is a report that acetaminophen may have a role in pharmacological closure of PDA
(Patent arterial duct) in preterm infants.
The investigators conducted this open label non randomized and non control study to try to
support that report.
In-uteri, the arterial duct connects between the aorta and the main pulmonary artery, thus
bypassing the lungs. Since the high pulmonary pressure and the low systemic pressure, the
shunt trough the arterial duct in that time is right to left.
After birth, systemic pressure rises and pulmonary pressure declines. As oxygen saturation
rises, and prostaglandin secretion, the arterial duct closes, usually. In preterm infants,
the arterial duct may remain open after birth. At this tume the shunt would be left to right,
that would cause pulmonary congestion, and systemic hypoperfusion.
Ibuprofen is the treatment of choice for PDA in preterm infants. Yet, ibuprofen is not
effective after two weeks of age. Moreover, there are situations that prevent treatment with
ibuprofen, such as thrombocytopenia or renal failure. Surgical closure of arterial duct is an
alternative treatment, if ibuprofen is contraindicated, or if it fails.
Lastly, there was a report that acetaminophen may have a role in pharmacological closure of
PDA in preterm infants.
The investigators conducted this open label non randomized and non control study to try to
support that report.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02396004 -
NIRS in PDA VLBW Infants
|
N/A | |
| Completed |
NCT05321849 -
Echocardiography-guided Percutaneous Patent Ductus Arteriosus Closure
|
||
| Completed |
NCT04379843 -
The Efficacy of Implementing a Treatment Algorithm in Managing Patent Ductus Arteriosus (PDA) in the Extremely Low Birth Weight Neonatal Population.
|
||
| Recruiting |
NCT01149564 -
Comparison of Oral and Intravenous Ibuprofen for PDA Treatment in Premature Infants
|
Phase 1/Phase 2 |