Patients Who Underwent Allograft Clinical Trial
Official title:
Treatment of Adenovirus Disseminated Infections in Hematopoietic Stem Cell Transplant Patients With Adenovirus Digestive Replication- A Pharmaco-epidemiological Prospective Study
Disseminated Adv infections are associated with high morbidity and mortality in HSCT
pediatric patients. The most common source of Adv infection after pediatric HSCT is the host
digestive tract where latent Adv are reactivated after engraftment. We have shown in a
monocentric study that Adv viral load in stools is a predictive factor of blood infection in
children with digestive Adv infections. We assume that an early treatment, with antiviral
drugs, such as cidofovir and brincidofovir, may avoid severe Adv infections and diseases and
thus that molecular surveillance in stool is a critical factor for the control of Adv
reactivations.
The study has two main objectives: (i) confirming the impact of Adv viral load in stools on
the occurrence of blood infection based on a multicentric prospective cohort study design;
and (ii) determining the prognostic and predictive factors for efficacy and toxicity of
antiviral drugs, such as brincidofovir and cidofovir.
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