Clinical Trial Details
— Status: Completed
Administrative data
| NCT number |
NCT04708119 |
| Other study ID # |
19-KAEK-081 |
| Secondary ID |
|
| Status |
Completed |
| Phase |
N/A
|
| First received |
|
| Last updated |
|
| Start date |
April 1, 2019 |
| Est. completion date |
July 15, 2020 |
Study information
| Verified date |
January 2021 |
| Source |
Tokat Gaziosmanpasa University |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Interventional
|
Clinical Trial Summary
This study aimed to evaluate the incidence of histopathologic changes in dental follicles
associated with radiographically normal impacted lower third molar and to determine the
relationship between cystic changes in follicle tissues and age, gender, and the angular
position of the impacted tooth.
Description:
Patients One hundred one healthy patients whose ILTM were extracted for various reasons in
Tokat Gaziosmanpaşa University, Faculty of Dentistry, Department of Oral and Maxillofacial
Surgery were included in the study. All participants included in the study signed an informed
consent form. The study was conducted in accordance with the Declaration of Helsinki, and the
protocol was approved by Tokat Gaziosmanpaşa University Clinical Research Ethics Committee
for the study (Project number: 19-KAEK-081).
The patients' panoramic radiographs were examined, and the impacted teeth were divided into
four groups as vertical, horizontal, mesioangular, and distoangular according to their
angular positions. The radiographically found that patients with a follicular width of less
than 2.5 mm were included in the study. The follicular tissues were also excised after tooth
extraction. Soft tissue samples taken during surgical removal of ILTM were evaluated in the
department of pathology.
Histopathological evaluation The excision materials obtained for the study were subjected to
routine tissue follow-up procedures in Tokat Gaziosmanpaşa University, Faculty of Medicine,
Pathology Department. The samples were fixed in 10% formalin solution for 24 hours for light
microscope examination and blocked using the routine paraffin blocking method. The
preparations were prepared by obtaining sections with microtome from the blocks. These
preparations were stained with Hematoxylin Eosin and evaluated under a light microscope. In
the histopathological examination, squamous epithelium, keratinization, odontogenic
epithelial residue, and fibrosis were evaluated as either present or absent, and inflammation
was scored as 0-absent, 1-mild, 2-moderate, or 3-severe. During the microscopic evaluation of
follicular tissues, soft tissue samples with stratified squamous epithelium were identified
as cystic.
The relationship between histopathological changes observed in the radiographically normal
dental follicles and gender and the teeth' angular positions was statistically evaluated.
