Normal Ventilatory and Perfusion Pulmonary Function in TEMP

Patents With Normal VQ/SPECT Clinical Trial

— 3DSPECSTAT  

Official title:

Normal Ventilatory and Perfusion Pulmonary Function in TEMP: Generation of 3D Statistical Maps From Normal Examinations

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04332406
• Other study ID #: 29BRC19.0129
• Status: Completed
• Start date: June 13, 2019
• Est. completion date: October 15, 2019

Study information

• Verified date: April 2020
• Source: University Hospital, Brest
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Ventilation - perfusion SPECT is attractive for lung function assessement. Unfortunately, it is very difficult to delineate normal to abnormal areas because of physiological uptake heterogeneity.

In that context, it would be of interest to build statistical maps from registrered normal studies and propose a new methodology for normal SPECT delineation

Description:

Patients with normal VQ SPECT-CT will be analysed. After a image proccesing workflow including rigid registration, non rigid registration and normalization, a voxelized mean and standard deviation map will be created. Those maps will be analyzed in regards of physiology and litterature.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 96
• Est. completion date: October 15, 2019
• Est. primary completion date: October 15, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• normal perfusion and ventilation scans, and no parenchyma or pleural abnormality on low dose CT

• confirmation by a second senior physician

Exclusion Criteria:

Patients with history of pulmonary disease:

• chronic obstruction pulmonary disease,

• previous pulmonary embolism,

• surgery of the lungs

• radiotherapy of the lungs

Related Conditions & MeSH terms

• Patents With Normal VQ/SPECT

Locations

Country	Name	City	State
France	Médecine nucléaire - Hôpital Morvan (CHRU de Brest)	Brest

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Brest

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Posterior to Anterior and Inferior to Superior uptake relative difference on parametric mean registered SPECT map versus non registered SPECT	parametric mean and standard deviation maps are build from elastic registration of normal lung V/Q SPECT-CT. A ROI based quantitative regional uptake comparison is performed to verify the influence of elastic registration on radiotracer distribution	through study completion, an average of 3 months