Partial Hearing Loss Clinical Trial
Official title:
Genetic Analysis of Human Hereditary Hearing Impairment
| Verified date | April 7, 2015 |
| Source | National Institutes of Health Clinical Center (CC) |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Observational |
This studied is designed to discover the genes that cause hearing impairment. More precisely,
this study aims to map and clone genes that are important for the development and maintenance
of the anatomy and physiology related to hearing (auditory system).
The study will begin by finding large families who have members with hearing impairment. Once
families are found, members with and without hearing impairment will be evaluated by an
audiologist and a clinician (doctor). An audiologist, is a person trained in evaluating,
habilitating, and rehabilitating people with disorders of hearing function. The clinician's
responsibility is to examine the patients and check for other signs and symptoms related to
hearing.
Finding the gene for hearing impairment requires:
1. <TAB>DNA samples of hearing impaired family members, taken from standard blood samples.
2. <TAB>DNA samples of members of the family without hearing impairment, taken from
standard blood samples.
3. <TAB>Results of hearing tests conducted by the audiologist for all participants.
Once all members of the family are evaluated researchers can create a pedigree. A pedigree is
like a family tree that charts members of a family with a genetic disorder, like hearing
impairment. Pedigrees are used to determine the mode of inheritance of the gene responsible
for a particular condition.
Finally, researcher intend on using all the information gathered as well as methods for
genetic analysis to map out the location of the gene. Patients participating in this study
will not directly benefit from its research, but scientific understanding achieved may help
researchers better understand the auditory system and someday prevent deafness.<TAB>...
| Status | Terminated |
| Enrollment | 404 |
| Est. completion date | April 7, 2015 |
| Est. primary completion date | |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | N/A and older |
| Eligibility |
- INCLUSION CRITERIA: It is anticipated that, in most cases, patients will be recruited whose disorders do not appear to be syndromic (i.e. are not associated with extra-auditory or extra-vestibular features). We seek subjects who are members of large families with multiple individuals affected with a hearing disorder. Sporadic cases will occasionally be included when the phenotype has features suggestive of mutations in one or a few particular candidate genes, since autosomal or X-linked recessive inheritance can appear to be sporadic. If there is evidence of genetic homogeneity, small families can be pooled for linkage analysis, or a combination of large and small families can be pooled. Subjects of any ethnic background, gender, age, sexual orientation, or health status will be included. EXCLUSION CRITERIA: Patients will be excluded when their hearing or vestibular dysfunction are known to be caused by a nongenetic etiology such as trauma, infection, metabolic or immunologic disorders, or exposure to ototoxic agents such as noise or aminoglycoside antibiotics. |
| Country | Name | City | State |
|---|---|---|---|
| United States | National Institutes of Health Clinical Center, 9000 Rockville Pike | Bethesda | Maryland |
| Lead Sponsor | Collaborator |
|---|---|
| National Institute on Deafness and Other Communication Disorders (NIDCD) |
United States,