Parkinsonian Syndrome Clinical Trial
Official title:
Dynamic SPECT Imaging With [123I] B-CIT in Individuals With Parkinsonian Syndrome (PS) and in Individuals at Risk for Parkinsonian Syndrome
This study involves study participants who have been clinically diagnosed with parkinsonian syndrome or who are at-risk for parkinsonian syndrome, have a family history of parkinsonian syndrome or exposure to environmental toxins potentially associated with parkinsonian syndrome. Participants will have brain imaging to assess dopamine transporter density. The imaging data coupled with family history and environmental exposure data may provide important information about potential risk factors for parkinsonian syndrome.
The brain imaging is conducted at the Institute for Neurodegenerative Disorders in New
Haven, Connecticut. The imaging procedure occurs over a two day period.
On the first day participants are injected with [123I]ß CIT, an investigational radioactive
material that localizes in the brain. Study participants will also have a thorough
neurologic examination and standard neuropsychological testing, including testing of memory,
concentration, abstraction and visual spatial functions.
Twenty-four hours later study participants return to the Institute for Neurodegenerative
Disorders where an investigational scanning procedure will be used to obtain SPECT (single
photon emission computed tomography) images of the brain.
Participants may be contacted to repeat these procedures every 12 to 18 months.
;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT00132626 -
Study of Brain Imaging With Nuclear Technology in Individuals With Parkinsonian Syndrome
|
Phase 2 | |
| Completed |
NCT00368199 -
Transcranial Duplex Scanning and Single Photon Emission Computer Tomography (SPECT) in Parkinsonian Syndromes
|
N/A | |
| Completed |
NCT00096876 -
A Study of the Sense of Smell in Relatives of Parkinson's Disease Patients
|
||
| Completed |
NCT00117195 -
A Study of Neurophysiologic Changes in Individuals With Parkinson's Disease
|
N/A | |
| Completed |
NCT04193527 -
A Study to Evaluate the Diagnostic Efficacy of DaTSCAN™ Ioflupane (123I) Injection in Single Photon Emission Computed Tomography (SPECT) for the Diagnosis of Parkinsonian Syndrome (PS) in Chinese Patients
|
Phase 3 | |
| Completed |
NCT04974034 -
Movement Disorders Analysis Using a Deep Learning Approach
|
||
| Completed |
NCT00354003 -
The Study of the Impact of Disclosing Imaging Study Information to Trial Participants
|
||
| Completed |
NCT04925622 -
Complex Eye Movements in Parkinson's Disease and Related Movement Disorders
|
||
| Completed |
NCT00273351 -
Imaging and Genetic Biomarkers of Parkinson Disease (PD) Onset and Progression in High-risk Families
|
Phase 2 | |
| Completed |
NCT00315250 -
Development of Imaging, Clinical and Biochemical Bio-Markers for Parkinson's Disease
|
Phase 2 | |
| Completed |
NCT00129181 -
Study of the Effects of Dopaminergic Medications on Dopamine Transporter Density in Subjects With Parkinson's Disease
|
N/A | |
| Completed |
NCT00096720 -
Study of the Effects of Dopaminergic Medications on Dopamine Transporter Imaging in Parkinson's Disease
|
Phase 2 | |
| Completed |
NCT00129675 -
Study of Individuals With Parkinson's Symptoms But in Whom There is Diagnostic Uncertainty
|
Phase 2 | |
| Recruiting |
NCT05110547 -
Multicenter Study of Blood Biomarkers of Mitochondrial and Peroxisomal Metabolism to Differentiate Idiopathic Parkinson's Disease From Related Conditions
|