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Parathyroid Neoplasms clinical trials

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NCT ID: NCT05696405 Completed - Hyperparathyroidism Clinical Trials

VATS for Resection of Mediastinal Parathyroids

Start date: January 1, 2008
Phase:
Study type: Observational

Background: hyperparathyroidism (HPT) is a disease caused by hypersecretion of one or more parathyroid glands, it can be associated with ectopic mediastinal parathyroid glands (MEPA) in 2% of cases. The use of video-assisted thoracoscopic surgery (VATS) for the surgical resection of these glands is a safe, cost-effective, and low-morbidity option for patients with MEPA. We report a case series of patients with this disease managed with VATS. Patients & Methods: From 2008 to 2022, a retrospective study involving patients with MEPA and treated by VATS approach was performed in a tertiary hospital in Mexico City. Relevant biochemical and clinical variables such as imaging studies, pre and postoperative lab results, surgical strategy and outcomes, and pathological analyses were analyzed.

NCT ID: NCT04905641 Completed - Thyroid Nodule Clinical Trials

The Feasibility of Bilateral Intermediate Cervical Plexus Block for Thyroidectomy/Parathyroidectomy

Start date: March 10, 2016
Phase:
Study type: Observational

The aim of this study was evaluated the feasibility of bilateral intermediate cervical plexus blockade to be anesthesia for simple thyroid/parathyroid surgery.

NCT ID: NCT04574947 Completed - Anesthesia Clinical Trials

Lidocaine And Neuromonitoring in Thyroid Surgery

Start date: January 25, 2021
Phase: Phase 4
Study type: Interventional

The aim of this study is to test the hypothesis that the quality of recovery with topical lidocaine is better than placebo.

NCT ID: NCT04570033 Completed - Hyperparathyroidism Clinical Trials

The Utility of 18F-fluorocholine PET/CT in the Imaging of Parathyroid Adenomas

Start date: January 1, 2016
Phase: N/A
Study type: Interventional

We assessed sensitivity of 18F-FCH PET/CT in preoperative localisation of hyperfunctioning parathyroid tissue in patients with primary hyperparathyroidism (PHPT).

NCT ID: NCT04344886 Completed - Clinical trials for Primary Hyperparathyroidism

Optimization and Individualization of Diagnostic Scintigraphy Protocol and Minimally Invasive Radio-guided Parathyroid Surgery

Start date: May 1, 2016
Phase: N/A
Study type: Interventional

The radio-guided technique offers both help with in-vivo identification and ex-vivo confirmation of parathyroid adenoma. In-vivo accuracy is most important but its results are not satisfactory. The aim of this study was to evaluate if there is a beneficial effect of individualized timing of surgery using preoperative multi-phase 99mTc-MIBI single-photon emission computed tomography (SPECT)/CT on in-vivo characteristics of minimally invasive radio-guided parathyroidectomy.

NCT ID: NCT04299425 Completed - Clinical trials for Primary Hyperparathyroidism

Evaluating Impact of NIRAF Detection for Identifying Parathyroid Glands During Parathyroidectomy

NIRAF
Start date: March 13, 2020
Phase: N/A
Study type: Interventional

This study describes a single center, randomized, single-blinded clinical trial to assess the clinical benefits of the use of near infrared autofluorescence (NIRAF) detection with an FDA-cleared device 'Parathyroid Eye (PTeye)' for identifying parathyroid glands (PGs) during parathyroidectomy (PTx) procedures. It compares risk-benefits and outcomes in PTx patients where NIRAF detection with PTeye for parathyroid identification is either used or not used.

NCT ID: NCT04040946 Completed - Hyperparathyroidism Clinical Trials

Trial Comparing 2 Diagnostic Strategies for Preoperative Localization of Parathyroid Adenoma in Primary Hyperparathyroidism:TEMP / CT With Tc99m-sestaMIBI or PET / CT With F18-choline in First Intention

APACH2
Start date: September 19, 2019
Phase: Phase 3
Study type: Interventional

The investigators hypothesize that positron emission tomography with fluorocholline (F18-choline PET) will reduce the proportion of unnecessary invasive surgery decisions and that the higher cost of positron emission tomography versus MIBI scintigraphy (Tc99m-sestaMIBI ) will be offset by lower cost in terms of type. surgery performed wisely and complications.

NCT ID: NCT03764007 Completed - Clinical trials for Hyperparathyroidism, Primary

18F-Fluorocholine for the Detection of Parathyroid Adenomas

Start date: September 21, 2016
Phase: Phase 2/Phase 3
Study type: Interventional

The investigators are studying the ability of F18 labeled fluorocholine PET to localize parathyroid adenomas in patients with hyperparathyroidism prior to surgery.

NCT ID: NCT03469310 Completed - Thyroid Cancer Clinical Trials

Minimizing Narcotic Analgesics After Endocrine Surgery

Start date: March 9, 2018
Phase: Phase 4
Study type: Interventional

This research is being done to better understand and test if the investigators can minimize narcotic medication for controlling pain after thyroid or parathyroid surgery. This research will be performed at Doctors Hospital At Renaissance in the investigators clinic and the perioperative area. Participants will be randomly chosen to receive one of two options for pain management that the investigators are already using in the care of patients after surgery. One option includes a narcotic medication and one option includes a non-narcotic and a narcotic as needed. Participants will be asked to complete a form about the level of pain and how much pain medication was needed after surgery in the hospital and while at home. Participants will not have to do any additional visits to participate in this study. The investigators will obtain the research materials at the same time as the usual care visits around the participants' surgery.

NCT ID: NCT03280264 Completed - Clinical trials for Primary Hyperparathyroidism

Phase 3 Study of KHK7580 for the Treatment of Hypercalcemia in Patients With Parathyroid Carcinoma or Primary Hyperparathyroidism

Start date: August 30, 2017
Phase: Phase 3
Study type: Interventional

To evaluate the efficacy of KHK7580 orally administered up to 24 weeks for hypercalcemia in patient with parathyroid carcinoma or primary hyperparathyroidism who are unable to undergo parathyroidectomy or relapse after parathyroidectomy.