Parathyroid Diseases Clinical Trial
— parathyroidOfficial title:
Clinical Value of 18F -Fluorocholine (18F-FCH) PET in Localizing Parathyroid Lesions: Comparison With 99mTc-sestamibi (MIBI) Scan.
Verified date | June 2019 |
Source | National Taiwan University Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This prospective study aims to
1. compare the detection rates among sonography, MIBI scan and 18F-FCH PET for localization
of the parathyroid lesions including adenoma, hyperplasia or carcinoma; evaluate the
usefulness of 18F-FCH PET as a second-line tracer in MIBI scan negative patients.
Status | Completed |
Enrollment | 103 |
Est. completion date | October 1, 2018 |
Est. primary completion date | June 2018 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 20 Years and older |
Eligibility |
Inclusion Criteria: - Parahyperthyroidism (serum iPTH 65 pg / mL; normal range : 12-65), merged with normal or high serum calcium concentration (serum calcium 2.35 mmol / L; normal range: 2.15-2.58) and normal or low serum phosphate concentration (serum phosphorus 3.75 mg / dL; normal range : 2.5-5.0). - High serum calcium concentration (serum calcium 2.58 mmol/L), but the blood parathyroid hormone concentration in normal range (serum iPTH 12-65pg / mL), hyperthyroidism is suspected. - MIBI scan has been performed or arranged. - Age:above 20 years old. Exclusion Criteria: - Patient with Familial hypocalciuric hypercalcemia:daily calcium excretion < 100 mg/24h and fractional excretion of calcium < 1%. - taking or was taking lithium. - vitamin D deficiency (25-OH vitamin D < 10 ng/mL). - Patients with pregnancy or recently having a plan for pregnancy. |
Country | Name | City | State |
---|---|---|---|
Taiwan | National Taiwan Univeristy Hospital | Taipei |
Lead Sponsor | Collaborator |
---|---|
National Taiwan University Hospital |
Taiwan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | PET imaging | By visual interpretation if there are focal areas of abnormal 18F-FCH accumulation. The presence, number, size, character, and location of suspected lesions will be filed for each patient in this study. | in 3 days |
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