Enterobius Vermicularis Infestation of the Appendix

Parasitic Disease Clinical Trial

Official title:

Enterobius Vermicularis in Appendectomy Specimens; Clinicopathological Assessment

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04576273
• Other study ID #: 3003
• Status: Completed
• Start date: June 1, 2017
• Est. completion date: May 31, 2020

Study information

• Verified date: September 2020
• Source: Al-Azhar University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study identifies the incidence of appendiceal Enterobius vermicularis (E.v) infestation in all the patients undergoing appendectomy and evaluates the relationship between E.v infestation of the appendix and the acute appendicitis.

Description:

All the patients undergoing appendectomy surgical procedure for clinical picture of acute appendicitis in 3-years period at our referral hospital were evaluated to pick up the Enterobius vermicularis infestation of the appendix. These cases were evaluated for clinico-laboratory characterization to define the incidence in our country and the relationship between the E.v and initiation of the the inflammatory process to study the possibility of limitation of surgical intervention in acute abdomen conditions.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 1150
• Est. completion date: May 31, 2020
• Est. primary completion date: May 31, 2020
• Gender: All
• Age group: 4 Years to 90 Years

Eligibility

Inclusion Criteria:

All routine examined appendectomy specimens

Exclusion Criteria:

Cases with clinical suspicion of tumor Cases attached to the colectomy specimens

Related Conditions & MeSH terms

• Parasitic Disease
• Parasitic Diseases

Intervention

Diagnostic Test:
• Pathology examination
Gross and microscopic evaluation

Locations

Country	Name	City	State
Saudi Arabia	Abdulkarim Hasan	Baljurashi

Sponsors (1)

Lead Sponsor	Collaborator
Al-Azhar University

Country where clinical trial is conducted

Saudi Arabia, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Association between acute inflammation and Enterobius vermicularis infestation	All the studied Enterobius vermicularis cases will be evaluated microscopically to record the count of acute inflammatory cells per millimeter (mm) and per High Power Field (HPF) using the microscope scale measurement. This count will be compared with the inflamed appendectomy specimens without Enterobius infestation to assess the hypothesis of the association between the Enterobius infestation and the acute appendicitis. Also special stain (congo red) will be implicated in some indicated cases to detect eosinophils, eosinophils will be positively staines (orange color stain means positive) if the stain is faint that means negative and the cell is not eosinophil	3 years
Primary	Incidence of Appendiceal Enterobius vermicularis	An incidence of Enterobius infestation will be assessed by studying all the received specimens during a 3 years-period using formatting a master sheet and processing in Excel program	3 years