Exendin PET/CT for Imaging of Paragangliomas

Paraganglioma Clinical Trial

— ENTRAP  

Official title:

Exendin PET/CT for Paragangliomas

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05418907
• Other study ID #: 2021-000194-93
• Status: Recruiting
• Start date: June 1, 2022
• Est. completion date: December 1, 2024

Study information

• Verified date: November 2023
• Source: Radboud University Medical Center
• Contact: Marti Boss, PhD
• Phone: +31243613813
• Email: marti.boss[@]radboudumc.nl
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Functional imaging of paragangliomas (PGLs) is not unequivocal. Existing functional imaging modalities show good but variable results in PGLs, warranting the search for additional molecular imaging targets. Investigators aim to evaluate the glucagon-like peptide 1 receptor (GLP-1R) as a novel target for molecular imaging of PGLs. For this purpose investigators will use the tracer 68Ga-NODAGA-exendin 4 for positron emission tomography/computed tomography (PET/CT) imaging.

Description:

Rationale:

Functional imaging of paragangliomas (PGLs) is not unequivocal. Existing functional imaging modalities show good but variable results in PGLs, warranting the search for additional molecular imaging targets. Investigators aim to evaluate the glucagon-like peptide 1 receptor (GLP-1R) as a novel target for molecular imaging of PGLs. For this purpose investigators will use the tracer 68Ga-NODAGA-exendin 4 for positron emission tomography/computed tomography (PET/CT) imaging.

Objective:

The primary objective is to examine the feasibility of 68Ga-exendin-4 PET/CT for localization and functional characterization of PGLs.

Study design:

In this prospective pilot imaging study 68Ga-exendin-4 PET/CT will be performed in 10 patients with confirmed PGL who have undergone CT, somatostatin receptor (SSTR) PET/CT and 18F-FDG PET/CT (as standard diagnostic procedures) and are scheduled for surgery. 100 ± 10 MBq 68Ga-NODAGA-exendin-4 will be administered to 10 patients in total. In the first 5 patients PET/CT imaging will be performed 1, 2 and 4 hours after injection to determine the optimal imaging timepoint for the remainder of the patients, which will be applied in the remaining patients.

The images will be reconstructed and evaluated by a nuclear medicine physician who is blinded to the results of the CT, SSTR PET/CT and 18F-FDG PET/CT to assess tumor detection. Additionally, quantitative analysis of 68Ga-exendin-4, SSTR PET and 18F-FDG PET/CT images will be performed. After the patients have undergone surgery, immunohistochemical analysis of surgical specimens will be performed to assess GLP-1R expression, which will be compared with in vivo tracer uptake.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 10
• Est. completion date: December 1, 2024
• Est. primary completion date: December 1, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Proven sympathetic PGL with a single tumor detected using standard diagnostic imaging

• No evidence of metastatic disease

• CT, SSTR PET/CT and 18F-FDG PET/CT performed (golden standard diagnostic imaging)

• Scheduled for surgery

• Able to sign informed consent

Exclusion Criteria:

• Breast feeding

• Pregnancy or the wish to become pregnant within 1 month

• Calculated creatinine clearance below 40ml/min

• Evidence of other malignancy than PGL in conventional imaging (suspicious liver, bone and lung lesions)

• Age < 18 years

• Not able to sign informed consent

Related Conditions & MeSH terms

• Paraganglioma

Intervention

Radiation:
• 68Ga-NODAGA-exendin-4 PET/CT
PET/CT imaging 1 hour after injection of 100 MB 68Ga-NODAGA-exendin-4

Locations

Country	Name	City	State
Netherlands	Radboud University Medical Center	Nijmegen

Sponsors (1)

Lead Sponsor	Collaborator
Radboud University Medical Center

Country where clinical trial is conducted

Netherlands, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	detection rate of PGL's using 68Ga-exendin-4 PET/CT	Detection based on visual inspection of PET/CT images	1 year
Secondary	optimal timepoint for imaging PGLs using 68Ga-exendin-4 PET/CT		After inclusion of the first 5 patients (up to 6 months)