Papulopustular Rosacea Clinical Trial
Official title:
An Open Label Phase 1b Study of Secukinumab in Patients With Moderate to Severe Papulopustular Rosacea
This is a study to determine whether secukinumab is a potential therapy for those with papulopustular rosacea. We will observe whether this drug decreases the size and/or amount and severity of the pustules of those who suffer from rosacea.
Rosacea is a common inflammatory skin disease affecting up to 10% of adults. Despite this,
the etiology of rosacea is unclear, although there may be a genetic predisposition (Chang et
al., 2015). Currently, there is no cure. Rosacea can lead to scarring, itching, burning, and
is associated with anxiety and depression (Moustafa et al., 2015), significantly affecting
quality of life.
Secukinumab is an antibody that binds to a protein (interleukin (IL)-17A) that is involved in
inflammation. When IL-17A is bound to secukinumab, it cannot bind to its receptor, thereby
inhibiting its ability to feed the inflammatory response. In clinical trials, secukinumab has
been effective for moderate to severe psoriasis (Blauvelt et al., 2015). Recently, human data
from all types of rosacea have shown Th1/Th17 polarization profile of the T-cell response,
suggesting that anti-IL-17 therapy may be beneficial for rosacea (Buhl et al., 2015). Hence,
secukinumab could be effective against rosacea. This proposal is a proof-of-concept study to
use secukinumab in open label design for moderate to severe papulopustular rosacea.
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