Papillary Thyroid Cancer Clinical Trial
— OTCancerOfficial title:
Overdiagnosis of Thyroid Cancer in the Marne and Ardennes Departments of France From 1975 to 2014
NCT number | NCT03623516 |
Other study ID # | 2017Ao001 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | January 1, 1975 |
Est. completion date | December 1, 2014 |
Verified date | July 2018 |
Source | CHU de Reims |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Introduction - Incidence of thyroid cancer has increased considerably in France in recent
years, but the mortality rate has declined only slightly. Part of this increased incidence
could be attributable to overdiagnosis. We aimed to estimate the contribution of
overdiagnosis to the incidence of papillary thyroid cancer.
Material and methods. - Incidence rates were calculated based on data from the specialised
Marnes-Ardennes thyroid cancer registry, for cancers diagnosed between 1975 and 2014, by age
category and by five-year period. The population was divided into two groups according to
pTNM classification at diagnosis (i.e. localised or invasive). Overdiagnosis was defined as
the difference in incidence rates between the invasive cancer and localised cancer groups.
This rate was then divided by the incidence rate in the localised cancer group for the most
recent period (2010-2014) to obtain the proportion of cancers attributable to overdiagnosis.
Status | Completed |
Enrollment | 2008 |
Est. completion date | December 1, 2014 |
Est. primary completion date | December 1, 2014 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - clinical doagnosis of papillary thyroid cancer - living in the Marne or Ardennes departments of France Exclusion Criteria: - cancer stage not determined |
Country | Name | City | State |
---|---|---|---|
France | Damien JOLLY | Reims |
Lead Sponsor | Collaborator |
---|---|
CHU de Reims |
France,
Saint-Martin C, Dramé M, Dabakuyo S, Kanagaratnam L, Arveux P, Schvartz C. Overdiagnosis of thyroid cancer in the Marne and Ardennes Departments of France from 1975 to 2014. Ann Endocrinol (Paris). 2017 Feb;78(1):27-32. doi: 10.1016/j.ando.2016.07.005. Epub 2016 Sep 15. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Overdiagnosis of thyroid cancer | Overdiagnosis of thyroid cancer (defined as the diagnosis of disease that would otherwise not go on to cause symptoms or death, and was calculated by comparing the incidence rate of the localised cancer group and that of the invasive cancer group) | 30 years |
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