Panic Disorder Clinical Trial
Official title:
CO2 Inhalation and Risk for Panic Disorder
Objective:
To examine respiratory/physiological and subjective responding as well as genetic
transmission among offspring of parents with a history of or current panic disorder (PD)
diagnosis to determine whether diagnoses/symptoms, endophenotypes, or genetic profiles in
offspring is differentially related to parent PD subtypes (i.e., respiratory and
non-respiratory panic).
Study population:
Approximately 400 offspring of about 200 parents with current or past PD. Approximately 200
offsping/100 parents with PD will be enrolled at NIH/NIMH and the remainder at Virginia
Commonwealth University in Richmond, VA.
Design:
A high-risk family design will be used wherein parents with either a current or past
diagnosis of PD who have an offspring(s) (ages 9 to 20) will be recruited.
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Outcome measures:
Outcome measures will include physiological recordings of respiratory, cardiac, and
electrodermal responding during a 10 minute baseline followed by 15 minutes of 5% carbon
dioxide enriched air (CO2). Research participants also will complete parent and child
self-report measures and provide a DNA sample using a saliva protocol. A full listing of
self-reports is provided in the Outcome Measures Section.
Objective:
The objective of this study is to examine respiratory/physiological and subjective responding
as well as genetic transmission among offspring of parents with a history of or current panic
disorder (PD) diagnosis. Our goal is to determine whether diagnoses/symptoms, endophenotypes,
or genetic profiles in offspring is differentially related to parent PD subtypes (i.e.,
respiratory and non-respiratory panic).
Study population:
Approximately 80 offspring between the ages of 9 and 20 years of age who have a parent with a
current or past history of PD will be recruited. Approximately 40 offspring will be enrolled
at NIH/NIMH and the remainder at Virginia Commonwealth University in Richmond, VA.
Design:
Offspring(s) between the ages of 9 to 20 who have a parent with a history of PD will be
recruited. A complete psychiatric history will be obtained on all child participants. Child
participants also will complete questionnaire measures, provide a sample of DNA, and
participate in a carbon dioxide CO(2) lab challenge. The CO(2) lab challenge is the primary
outcome measure.
Outcome measures:
Our primary outcome measures include physiological recordings of respiratory, cardiac, and
electrodermal responding during a 10 minute baseline followed by 15 minutes of 5% carbon
dioxide enriched air (CO(2). Research participants also will complete parent and child
self-report measures and provide a DNA sample using a saliva protocol. A full listing of
self-reports is provided in the Outcome Measures Section.
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