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Corticosteroids to Treat Pancreatitis — CRISP  

Pancreatitis Clinical Trial

Official title:
Corticosteroids to Reduce Inflammation in Severe Pancreatitis: A Randomized, Controlled Study

Clinical Trial Summary

This research is being done to determine if the administration of a short course of intravenous hydrocortisone, an anti-inflammatory medication, to patients with severe acute pancreatitis will improve their clinical outcomes and decrease the length of hospitalization. We think that because inflammation in the body drives the progression of pancreatitis, giving a short course of intravenous hydrocortisone may mitigate disease progression and improve clinical outcomes in patients with severe acute pancreatitis.

Clinical Trial Description

This is a randomized, double-blind, placebo controlled study to investigate the effect of intravenous hydrocortisone on clinical outcomes in patients with severe acute pancreatitis. The interventional drug is Hydrocortisone (100 mg of hydrocortisone in 50 milliliters of saline solution). The placebo is saline and is identical in appearance and volume to the interventional drug. Study drug will be administered intravenously every 8 hours for 72 hours as per standard clinical procedures by nursing staff. The patient's sequential organ failure assessment score (SOFA) will be assessed for changes over time. Blood will be drawn at several time points to assess biomarkers over time. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05160506
Study type Interventional
Source Beth Israel Deaconess Medical Center
Contact Michael Donnino, MD
Phone 6177542295
Email mdonnino@bidmc.harvard.edu
Status Recruiting
Phase Phase 2
Start date March 6, 2022
Completion date April 2027
View Details
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