Aggressive Fluid Hydration for the Prevention of Post-ERCP Pancreatitis

Status Completed

Clinical Trial Summary

Aggressive hydration with lactated Ringer's solution (LRS) has been shown in a preliminary research to reduce the incidence of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. This randomized, controlled trial was designed to assess the effect of peri-procedural aggressive intravenous hydration with LRS on the incidence of post ERCP pancreatitis.

Clinical Trial Description

Patients underwent first-time ERCP were randomly assigned (1:1) to receive either LRS at a rate of 150 ml/hr starting 2 hours prior to procedure, and continued during and after procedure to complete 24 hours (aggressive hydration) or LRS at a rate calculated by the Holliday-Segar method given peri-procedurally as described earlier (standard hydration). Visual analog scale, serum amylase, lipase, C-reactive protein (CRP), and urine analysis were assessed prior to procedure and 24 hours after. The primary endpoint was post ERCP pancreatitis defined as new or increased epigastric pain persisting for ≥24 hours, elevation of amylase or lipase >3 times the upper limit of normal. ;

Study Design

Related Conditions & MeSH terms

Pancreatitis

Clinical Trial Details

NCT number	NCT02821546
Study type	Interventional
Source	Mahidol University
Contact
Status	Completed
Phase	Phase 3
Start date	August 2014
Completion date	February 2017

View Details

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