Pancreatitis Clinical Trial
Background: Polyamines are essential compounds in all mammalian tissues. If tissue
spermidine/spermine levels, however, dramatically decrease, the cellular survival is
severely endangered. Transgenic animals, where the homeostasis of cellular polyamines can be
disturbed and tissue spermidine/spermine levels are decreased, acute pancreatitis evolves,
indicating pancreas to be one of the most vulnerable organs for tissue polyamine catabolism.
On the other hand, our own data suggests that also in other models of acute experimental
pancreatitis pancreatic polyamines are changed depending on the severity of pancreatitis in
such a way that the more severe pancreatitis the lower are the pancreatic polyamine levels.
Minor changes were observed also in rats undergoing sham operation only. In addition of
pancreatic enzymes, inflammatory mediators are also involved in the pathophysiology of the
disease. CRP, IL-6, IL-8, IL-10 and Procalcitonin are useful in predicting the severity of
the disease, combination of IL-6 and IL-10 at admission can predict organ failure with
sensitivity of 95 %, specificity of 88 %.
Hypothesis: Similar to experimental pancreatitis, blood polyamine changes are associated
with acute pancreatitis also in the man. These changes are dependent on the severity of
pancreatitis, but not on the etiology of pancreatitis. The changes are specific to acute
pancreatitis compared with other intra-abdominal emergencies. The changes observed return to
baseline during recovery. Furthermore, we assume that blood polyamine negatively correlates
with IL-6, IL-8, and procalcitonin, and positively with IL-10.
n/a
Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Cross-Sectional
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