Comparison of Efficacy of ESWL & Laser Lithotripsy in Chronic Pancreatitis

Status Not yet recruiting

Clinical Trial Summary

This study will compare the efficacy of ESWL and Laser Lithotripsy in the treatment of pancreatic duct stones with ERCP.

Clinical Trial Description

Chronic pancreatitis (CP) is an inflammatory disease that can causes progressive fibrosis of pancreatic tissue and eventually leads to damage of pancreatic exocrine and endocrine. According to statistics, the prevalence of CP in China is 13/10 million, which is still increasing. Pancreatic duct stones are the most important pathological changes of CP. More than 50% of patients with CP are accompanied by pancreatic duct stones, which can lead to pancreatic duct obstruction, hypertension and tissue ischemia. Removal of pancreatic duct stones under Endoscopic Retrograde Cholangiopancreatography (ERCP) are the first choice. ERCP is effective in the treatment of pancreatic duct stones by using basket and/or balloon catheter. But in most cases, ERCP is only suitable for the treatment of pancreatic duct stones (diameter < 5mm) located in the head/body of the Pancreatic Duct (PD). PD stones larger than 5mm generally require Extracorporeal Shock Wave Lithotripsy (ESWL) or Endoscopic Intraductal Lithotripsy (EIL) for pretreatment. EIL includes Electrohydraulic Lithotripsy (EHL) and Laser Lithotripsy (LL). ESWL first locates the stone by X-ray, and then uses an electromagnetic pulse generator to direct a higher-energy shock wave to the stone, so that the stone is crushed by thousands of shock waves. The principle of laser lithotripsy is to make the stone absorb strong infrared rays and generate shock waves to achieve the purpose of fragmenting the stone. In view of the fact that there is no relevant research comparing the overall efficacy of ESWL combined with ERCP and EIL combined with ERCP, it is necessary to evaluate the differences in the therapeutic effects and complications of the two for PD stones. This research helps to provide evidence-based medical evidence, guide physicians' clinical practice, improve the quality of patients' lives, and reduce the economic burden of patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05326542
Study type	Interventional
Source	Changhai Hospital
Contact	Liang-hao Hu, MD
Phone	+86-13817593520
Email	ianghao-hu@smmu.edu.cn
Status	Not yet recruiting
Phase	N/A
Start date	September 2022
Completion date	December 2022

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT01551511` - Δ9-THC (Namisol®) in Chronic Pancreatitis Patients Suffering From Persistent Abdominal Pain	Phase 2
Completed	`NCT01731821` - Nonstented Stump-closed vs Duct-to-Mucosa Pancreaticojejunostomy After Pancreaticoduodenectomy	Phase 3
Active, not recruiting	`NCT05095831` - EUS Shear Wave for Solid Pancreatic Lesions.
Completed	`NCT03173118` - Elastography in the Diagnosis of Chronic Pancreatitis	N/A
Terminated	`NCT01318590` - Prospective Study on Endoscopic Ultrasound (EUS) Celiac Bloc Efficacy in Chronic Pancreatitis	Phase 3
Recruiting	`NCT05772234` - Aggressive Intravenous Hydration With Lactated Ringer's Solution for Prevention of Post-ESWL Pancreatitis	N/A
Recruiting	`NCT04131010` - Digital Catheter Based Pancreatoscopy (SpyGlassDS) for the Management of Symptomatic Pancreatic Duct Stones in Selected Patients With Chronic Pancreatitis	N/A
Terminated	`NCT00359320` - A Randomized Trial of Two Surgical Techniques for Pancreaticojejunostomy in Patients Undergoing Pancreaticoduodenectomy	N/A
Completed	`NCT02940067` - Enhancing Fitness Before Pancreatic Surgery	N/A
Recruiting	`NCT05261997` - Endotherapy for Painless Chronic Pancreatitis	N/A
Not yet recruiting	`NCT05270434` - Optimal Timing of Endoscopic Intervention in the Treatment of Chronic Pancreatitis.	N/A
Completed	`NCT03672422` - Pediatric Longitudinal Cohort Study of Chronic Pancreatitis
Enrolling by invitation	`NCT05287737` - Clinical Outcome After Total Pancreatectomy With Islet Autotransplantation
Not yet recruiting	`NCT06426160` - Tocilizumab for Painful Chronic Pancreatitis	Phase 2
Enrolling by invitation	`NCT05289362` - Comparison of Efficacy of Basket and Balloon in the Removal of Pancreatic Duct Stones in Chronic Pancreatitis Under ERCP	N/A
Not yet recruiting	`NCT04760847` - Intermittent Fasting for Pancreatitis	N/A
Enrolling by invitation	`NCT03228095` - Volatiles in Breath and Headspace Analysis - Diagnostic Markers
Completed	`NCT00956839` - Prospective Study of Efficacy of Intra-muscular Vitamin D3 in Tropical Calcific Pancreatitis	Phase 4
Completed	`NCT00676702` - A Study of the Enzyme Activity and Safety of Pancrelipase in Patients With Severe Exocrine Pancreatic Insufficiency (EPI)	Phase 1
Recruiting	`NCT04672642` - Evaluation of the SpyGlass DS for Detection of Residual Pancreatic Calculations	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Comparison of Efficacy of ESWL and Laser Lithotripsy in Chronic Pancreatitis With ERCP

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms