Pancreatitis, Acute Necrotizing Clinical Trial
Official title:
The Study of Laparoscopic-assisted Percutaneous Catheter-directed Drainage to Treat Early Severe Acute Pancreatitis in Chinese Population.
The purpose of this study is to analyze the effect of laparoscopic-assisted percutaneous
catheter drainage of early SAP(severe acute pancreatitis).We are going to select 60 cases
SAP patients from April 2014 to April 2015 who carry on the treatment in our hospital,and
divide into the experimental group and control group under respect the wishes of patient in
the case.The experimental group use the method of laparoscopic-assisted percutaneous
drainage to carry on the treatment,the control group patients use conventional conservative
therapy to carry on the treatment.Contrastive analyze two groups of patients clinical care
effects.
Research hypothesis:according to compare the mortality,the incidence of complications
,hospital stay and other research indicators of two groups .It is supposed that the research
indicators of experimental group are lower than the control group ,difference was
statistically significant(P<0.05).We can draw the conclusion that the method of
laparoscopic-assisted percutaneous catheter drainage of early SAP is useful and deserve to
be promoted on clinical.
According to the unified inclusion and exclusion criteria,We are going to select 60 cases
SAP patients who carry on the treatment in our hospital from April 2014 to April 2015,and
divide into the experimental group and control group under respect the wishes of patients.
The experimental group use the method of laparoscopic-assisted percutaneous
catheter-directed drainage of SAP.According to different causes,.For patients with simple
gallbladder stones,it is going to carry out by laparoscopic cholecystectomy or
cholecystotomy.For patients with both gallbladder and common bile duct stones,common bile
duct exploration is performed.Removing necrotic pancreatic organizations and putting the
catheter around the region of pancreas.After the surgery,patient's cavity are continuously
douched by catheter using 0.5% 5-fluorouracil normal saline.The postoperation therapeutic
program is same as the control group.
The control group use the method of conventional conservative therapy without surgical
management,the principles of treatment include:(1)fasting,insert gastric
tube,gastrointestinal decompression;(2)complement of blood volume,keeping water ,electrolyte
and acid base balance;(3)inhibiting pancreatic enzyme and acid secretion;(4)using
broad-spectrum antibiotic at the early phase;(5)improving microcirculation,dextrans and
FuFangdanshen by IV;(6)early parenteral nutrition;(7)treatment by chinese
herbs;(8)strengthen the function of important organs.
Contrastive analyse two groups of patient's mortality,the incidence of
complications,hospital stay,laboratory tests and other research indicators.
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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