Clinical Trials Logo

Clinical Trial Summary

Overall morbidity rate remained high after distal pancreatectomy (DP), ranging from 30% to 60%. Whilst postoperative pancreatic fistula (POPF) remains serious and also is one of the most common complications after DP (12% to 40%). POPF after DP is also associated with major complications such as bleeding or septic shock and remains an equivocal problem. However, all the previous reports were retrospective review, non-randomized study, or individual experience and showed no significant improvement of overall POPF. As always, this issue remains in obscurity and seek for a more concrete evidence to solve.


Clinical Trial Description

Pancreatic surgery has been called formidable operation not only the technical challenge to surgeons but also demanding for patients. It evolved into a safe procedure with mortality rates of <5% recently, cutting down gradually from 25% in the 1960s. However, overall morbidity rate remained high ranging from 30% to 60%.

Distal pancreatectomy (DP) has been believed a safer and minor procedure compared with pancreatic head resection including standard pancreaticoduodenectomy (PD), pylorus-preserving pancreaticoduodenectomy (PPPD), or duodenum-preserving pancreatic head resection (DPPHR). Whilst postoperative pancreatic fistula (POPF) remains serious and also is one of the most common complications after DP. Büchler et al observed that the POPF rate was in fact significantly higher after DP when compared to pancreatic head resections. The variable documented incidence of POPF following DP ranges from 12% to 40%. POPF after DP is also associated with major complications such as bleeding or septic shock and remains an equivocal problem.

Although the majority of complications are not life-threatening, POPF could prolong hospitalization, expend expenditure for healthcare, abrade the quality of life; moreover, delay in further management for a fraction of patients with malignancy. Over the past two decades, various risk factors and multitudinous operative procedures have been held for reduction POPD following DP. These include underlying disease process, method of stump closure, and concomitant splenectomy However, all these reports were retrospective review, non-randomized study, or individual experience. As always, this issue remains in obscurity and seek for a more concrete evidence to solve. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03201653
Study type Interventional
Source National Taiwan University Hospital
Contact Ting-Chun Kuo, MD
Phone +886-2-23123456
Email tina@ntuh.gov.tw
Status Recruiting
Phase N/A
Start date July 2017
Completion date December 2019

See also
  Status Clinical Trial Phase
Completed NCT01696903 - Evaluation of a Novel Pancreaticojejunostomy Technique for Pancreaticoduodenectomy N/A
Completed NCT01301222 - Role of Octreotide in Preventing Pancreatic Fistula After Pancreaticoduodenectomy (PD) in Patients With Soft Pancreas Phase 4
Recruiting NCT05155878 - Prognostic Factors in Periampullary Tumors and Cysts
Terminated NCT03757455 - ERAS Protocol in Pancreaticoduodenectomy and Total Pancreatectomy N/A
Recruiting NCT05212350 - Total pancrEaTectomy vs High-Risk Pancreatic anastomosiS N/A
Completed NCT04609137 - Early Drain Removal Versus Standard Drain Management After Distal Pancreatectomy (Early-Dist) N/A
Recruiting NCT04798560 - Identifing Risk Factors for Pancreaticojejunostomy Leakage Following Pancreaticoduodenectomy
Completed NCT03627559 - Early Detection of Anastomotic Leakage by Microdialysis Catheters
Completed NCT01550406 - Use of Polyethylene Glycolic Acid or Tachocomb to Prevent Pancreatic Fistula Following Distal Pancreatectomy Phase 4
Recruiting NCT04783831 - Biodegradable Pancreatic Stents for the Prevention of Postoperative Pancreatic Fistula After Cephalic Pancreaticoduodenectomy
Not yet recruiting NCT05387538 - One-layer Versus Two-layer Duct-to-mucosa Pancreaticojejunostomy After Pancreaticoduodenectomy . N/A
Active, not recruiting NCT02775227 - HYPAR Trial - Hydrocortisone vs. Pasireotide in Reducing Pancreatic Surgery Complications Phase 4
Completed NCT02790333 - Different Stapler Cartridge For Pancreatic Stump Texture To Prevent Pancreatic Fistula N/A
Not yet recruiting NCT05657366 - Peritoneal Lavage on the Incidence of Pancreatic Fistula and Related Complications After Pancreatoduodenectomy N/A
Completed NCT03419676 - Use of Hemopatch as a Sealant at the Pancreaticojejunostomy After Pancreatoduodenectomy Phase 3
Recruiting NCT05297136 - Preoperative Endoscopic Pancreatic Stent for Distal Pancreatectomy N/A
Completed NCT00931554 - Randomized Trial of Early Versus Standard Drainage Removal After Pancreatic Resections N/A
Completed NCT00679952 - Closed Suction Drainage and Natural Drainage of the Pancreatic Duct in Pancreaticojejunostomy Phase 3
Recruiting NCT04380506 - Validations of New cut-of for the Stratification of Postoperative Complications,Drains Management N/A
Recruiting NCT06283160 - Metabolomic and Immune Profiling in the Development of Pancreatic Fistulas After Cephalic Duodenopancreatectomy