An Analysis of Presentation and Outcome Following Treatment of Pancreatic Endocrine Neoplasms

Pancreatic Endocrine Neoplasms Clinical Trial

Official title:

A Single Centre Analysis of Clinical Characteristics and Treatment of Endocrine Pancreatic Tumours.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02400996
• Other study ID #: SGRH-SGLT-MTA
• Status: Completed
• Phase: N/A
• First received: March 23, 2015
• Last updated: April 10, 2015
• Start date: March 2011
• Est. completion date: November 2014

Study information

• Verified date: April 2015
• Source: Medical College and Hospital Kolkata
• Contact: n/a
• Is FDA regulated: No
• Health authority: India: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

A single institutional study of Pancreatic Endocrine Neoplasms over 18 years.

Description:

The investigators did an analysis from a prospectively maintained database of patients who underwent pancreatic resections or nonresective procedures for neoplasms of the pancreas at Sir Ganga Ram Hospital from 1995 to 2013 and using pathological reports and preoperative CT scan as the gold standard, the investigators identified 40 patients with PENs.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: November 2014
• Est. primary completion date: June 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Pathological reports and Prooperative CAT Scan showing Endocrine Pancreatic Tumours

Exclusion Criteria:

• Nonendocrine Pancreatic Tumours

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Endocrine Gland Neoplasms
• Neoplasms
• Pancreatic Endocrine Neoplasms

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Medical College and Hospital Kolkata	Sir Ganga Ram Hospital

References & Publications (5)

Halfdanarson TR, Rabe KG, Rubin J, Petersen GM. Pancreatic neuroendocrine tumors (PNETs): incidence, prognosis and recent trend toward improved survival. Ann Oncol. 2008 Oct;19(10):1727-33. doi: 10.1093/annonc/mdn351. Epub 2008 May 30. — View Citation

Heitz PU, Komminoth P, Perrin A et al. Pancreatic endocrine tumors: Introduction. In: DeLellis DA, Lloyd RV, Heitz PU, et al., eds. Pathology and Genetics of Tumours of Endocrine Organs. WHO Classification of Tumours. Lyon, France: IARC Press, 2004: 177-8

Kazanjian KK, Reber HA, Hines OJ. Resection of pancreatic neuroendocrine tumors: results of 70 cases. Arch Surg. 2006 Aug;141(8):765-9; discussion 769-70. — View Citation

Vagefi PA, Razo O, Deshpande V, McGrath DJ, Lauwers GY, Thayer SP, Warshaw AL, Fernández-Del Castillo C. Evolving patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms: the Massachusetts General Hospital experience from 1977 to 200 — View Citation

Vortmeyer AO, Huang S, Lubensky I, Zhuang Z. Non-islet origin of pancreatic islet cell tumors. J Clin Endocrinol Metab. 2004 Apr;89(4):1934-8. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Nonfunctioning and Malignant Pancreatic Endocrine Neoplasms	Of the 40 patients operated for Pancreatic Endocrine Neoplasms, using clinical criteria, histopathological analysis and preoperative imaging as gold standard, nonfunctioning and functioning tumours were identified. Similarly the number of benign and malignant lesions identified were recorded as per the WHO Classification of pancreatic endocrine tumours.	Each participant was followed up for a period of 5 years	No