Survival Among Patients With Pancreatic Cancer Depending on Surgical Resection Rate

Pancreatic Ductal Adenocarcinoma Clinical Trial

Official title:

Survival Among Elderly Patients in Sweden With Right-sided Pancreatic Adenocarcinoma Depending on Resection Rate of Pancreaticoduodenectomy

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04802993
• Other study ID #: 2017/151-31
• Status: Completed
• Start date: January 1, 2010
• Est. completion date: October 2, 2020

Study information

• Verified date: March 2021
• Source: Linkoeping University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

The primary aim of this population-based study is to investigate how a high resection rate of pancreaticoduodenectomy affects overall survival among patients aged ≥70 years with pancreatic ductal adenocarcinoma. The secondary aim is to determine if a high resection rate of pancreaticoduodenectomy increases perioperative morbidity.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 5123
• Est. completion date: October 2, 2020
• Est. primary completion date: October 2, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Diagnosed between 1 January 2010 and 31 December 2018

• Registered in the Swedish National Registry for tumours in the pancreatic and periampullary region

• Either a diagnosis of pancreatic ductal adenocarcinoma of the pancreatic head or having been resected with pancreaticoduodenectomy

Exclusion Criteria:

• None

Related Conditions & MeSH terms

• Adenocarcinoma
• Pancreatic Ductal Adenocarcinoma

Intervention

Other:
• Resection rates
All groups are divided into one high- and one low resection rate group depending on percentage of patients with pancreatic ductal adenocarcinoma resected per county and year (first three groups) and resection rate of pancreaticoduodenectomy per 100 000 inhabitants per county (last three groups)

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Linkoeping University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Overall survival	Overall survival among patients aged 70 years and over with pancreatic ductal adenocarcinoma in the pancreatic head	A little more than 10 years (from first patient to vital status)
Secondary	Severe complications after pancreaticoduodenectomy	The rate of severe complications among patients aged 70 years and over who had undergone pancreaticoduodenectomy for any reason	Around 10 years (patients diagnosed between 1 January 2010 and 31 December 2018, latest dismissal from hospital january 2020)