Signature for Precise Chemosensitivity Prediction in PDAC

Status Completed

Clinical Trial Summary

Pancreatic ductal adenocarcinoma (PDAC) is largely heterogeneous. We sought to develop and validate a signature to precisely predict chemotherapy sensitivity in PDAC. Genetic events of the four most commonly mutated genes in PDAC and expressions of 12 PI3K/AKT/mTOR pathway markers were examined in consecutive patients with PDAC. A 9-feature signature for prediction of chemotherapy benefits was constructed using the LASSO Cox regression model, and validated in two independent cohorts.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Pancreatic Cancer

Clinical Trial Details

NCT number	NCT06461598
Study type	Observational
Source	Ruijin Hospital
Contact
Status	Completed
Phase
Start date	January 1, 2018
Completion date	May 31, 2021

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