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Evaluating Obesity-Mediated Mechanisms of Pancreatic Carcinogenesis in Minority Populations

Pancreatic Cancer Clinical Trial

Official title:
Evaluating Obesity-Mediated Mechanisms of Pancreatic Carcinogenesis in Minority Populations

Clinical Trial Summary

This study will evaluate obesity-mediated mechanisms of pancreatic carcinogenesis in minority populations.

Clinical Trial Description

This observational study will evaluate obesity-mediated mechanisms of pancreatic carcinogenesis in minority populations consisting of adult males or females, 18 years of age or older, who self-report as African American (AA) or Non-Hispanic White (NHW), and present to the gastrointestinal (GI) clinic, surgery, or endoscopy at a participating Florida Pancreas Collaborative (FPC) site or University of Mississippi Medical Center (UMMC) with a clinical suspicion or diagnosis of a pancreatic tumor. This study will also include patients who have been previously recruited as part of the FPC study. Our central hypothesis is that adipose tissue (AT) dysfunction contributes to malignant transformation, therapeutic resistance, and poor survival among obese AA pancreatic ductal adenocarcinoma (PDAC) cases and such dysfunction will be characterized by unique biology. The primary objective of this multi-institutional and multidisciplinary translational study is to identify a molecular and imaging profile unique to paired PDAC tumors and AT from AA and harness biological observations to predict therapeutic response and target novel obesity-mediated mechanisms of PDAC development and progression using in vitro, ex vivo, and in vivo techniques and new combinations of drug agents. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05687188
Study type Observational
Source H. Lee Moffitt Cancer Center and Research Institute
Contact
Status Recruiting
Phase
Start date February 22, 2023
Completion date December 2026
View Details
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