Pancreatic Adenocarcinoma Clinical Trial
Official title:
Clinical Study of Personalized mRNA Tumor Vaccine Encoding Neoantigen in Patients With Advanced Esophageal Squamous Carcinoma, Gastric Adenocarcinoma, Pancreatic Adenocarcinoma and Colorectal Adenocarcinoma
A single arm, open-label pilot study is designed to determine the safety, tolerability and effectiveness of personalized mRNA tumor vaccine encoding neoantigen in Patients with advanced esophageal squamous carcinoma, gastric adenocarcinoma, pancreatic adenocarcinoma and colorectal adenocarcinoma
Dr. Bin Wang developed the investigational vaccine used in this clinical trial and designed
the trial protocol.For patients with advanced esophageal squamous carcinoma, gastric
adenocarcinoma, pancreatic adenocarcinoma and colorectal adenocarcinoma tumor who have
disease progression with first line chemotherapy. Single or multiple doses of personalized
mRNA tumor vaccine encoding neoantigen will be given to observe the safety and efficacy the
mRNA tumor vaccine.
Primary objectives:
Determine the safety, tolerability and cytokinetics of the personalized mRNA tumor vaccine in
patients with advanced esophageal squamous carcinoma, gastric adenocarcinoma, pancreatic
adenocarcinoma and colorectal adenocarcinoma.
Secondary objectives:
Make a preliminary evaluation on the efficacy of personalized mRNA tumor vaccine in patients
with advanced esophageal squamous carcinoma, gastric adenocarcinoma, pancreatic
adenocarcinoma and colorectal adenocarcinoma with the following parameters:
Time of tumor progression (TTP);
Disease Control Rate (DCR);
Objective Remission Rate (ORR);
Overall Survival (OS).
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