Endothelial Leakage & the Association to Endothelial Biomarkers After

Status Completed

Clinical Trial Summary

The primary aim of this study is to investigate fluid loss from the blood stream (''endothelial leakage'') and the damage on the vessel wall (''endothelial function'') during surgery. Cardiovascular complications during surgery are said to have different causes, e.g. lack of fluid in the blood stream (''hypovolemia'') and decreased vascular tone. Hypovolemia can have different causes, one being damage to the endothelial function. During trauma and infection, it has been previously shown, that damage to the endothelial function causes fluid loss from the blood stream. Nevertheless, this has never been demonstrated during surgery. Secondary this study will measure the blood flow using a thermo-camera during surgery. This will together with selected blood tests provide information on various possible causes to hypovolemia. The purpose of this study is to describe and quantify endothelial damage (assessed by selected endothelial biomarkers) and albumin escape rate as a proxy for endothelial leakage (assessed by measuring radioactive 125-I labeled HSA injected postoperatively), combined with assessment of MTS (assessed by Laser Speckle Contrast Imaging (LSCI) and digital thermography). This will allow a detailed description of the surgery's impact on the endothelial integrity and contribute to a better understanding of the physiological changes that occur postoperatively. The study will investigate patients undergoing pancreaticoduodenectomy (Whipple) and total pancreatectomy. These patients have a vast clinical need, being one of the most extensive abdominal surgical procedures with great stress response. The study is a prospective exploratory cohort study and methods include blood sampling pre- and post-operatively, 125-I labeled humane serum albumin postoperatively (and preoperatively if logistically possible) and thermography. The hypothesis of this study is that the extent of endothelial damage measured by selected biomarkers is associated with the level of albumin escape rate after major abdominal surgery. Secondly, inflammation increases albumin escape rate after major abdominal surgery.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05333991
Study type	Observational [Patient Registry]
Source	Rigshospitalet, Denmark
Contact
Status	Completed
Phase
Start date	August 31, 2022
Completion date	November 1, 2023

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04559490` - Baby Formula and Health
Recruiting	`NCT05155878` - Prognostic Factors in Periampullary Tumors and Cysts
Recruiting	`NCT03260842` - Bio-Repository of High Risk Cohorts for the Early Detection of Pancreas Cancer
Completed	`NCT04609137` - Early Drain Removal Versus Standard Drain Management After Distal Pancreatectomy (Early-Dist)	N/A
Terminated	`NCT03553394` - Effects of Restrictive Fluid Strategy on Postoperative Oliguric Pancreatic Surgery Patients	N/A
Completed	`NCT01918813` - Risk of Methicillin-resistant S.Aureus (MRSA) Infections in MRSA Carrier Under Introduction of Rapid MRSA Screening	N/A
Recruiting	`NCT05714111` - Radiology Registry on Pancreatic Malignancies
Completed	`NCT04514198` - Postoperative Pancreatitis and Its Correlation With Clinically Relevant Pancreatic Fistula in Pancreaticoduodenectomy
Recruiting	`NCT04701567` - Diagnostic and Evaluation of Hepato-pancreatico-biliary Disease With MRI
Withdrawn	`NCT03598283` - Liver, Pancreas and Thyroid Function in Burn Patients
Recruiting	`NCT05431556` - Virtual Mind-Body Exercises for People Having Pancreatic Surgery	N/A
Not yet recruiting	`NCT06463873` - A Pilot Study of OmniGraft in Simultaneous Pancreas Kidney Recipients
Not yet recruiting	`NCT04760847` - Intermittent Fasting for Pancreatitis	N/A
Not yet recruiting	`NCT04900012` - Prospective Snapshot Audit of Distal Pancreatectomy in Spain
Recruiting	`NCT04556019` - Results of Surgical Treatment of the Hepatobiliopancreatic Surgical Unit
Completed	`NCT05139394` - Emergency Pancreaticoduodenectomy: a Non-trauma Center Case Series
Completed	`NCT06135233` - Implementation and Outcome of Minimally Invasive Pancreatoduodenectomy in Europe:
Completed	`NCT06160154` - Minimally Invasive Robot-assisted and Laparoscopic Distal Pancreatectomy in a Pan-European Registry
Completed	`NCT04898517` - Prevention of CR-POPF in PD With the Technique of Connexion the Pancreatic Duct to Jejunum Stented (CONDUCTJE-ST).
Completed	`NCT03169998` - Effect of Goal-directed Fluid Therapy on Postoperative Complications

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Endothelial Leakage and the Association to Endothelial Biomarkers After Surgery

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms