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Circulating Extracellular Exosomal Small RNA as Potential Biomarker for Human Pancreatic Cancer

Pancreas Adenocarcinoma Clinical Trial

Official title:
Diagnostic and Prognostic Values of EUS-FNA Specimens and Circulating Exosomal Small RNA in Patients With Pancreatic Cancer

Clinical Trial Summary

This study is for the verification of biomarkers for pancreatic cancer treatment using small RNA liquid biopsy, combined with EUS-FNA tissues.

Clinical Trial Description

CA19-9 is the FDA approved biomarker for the diagnosis of pancreatic cancer. However, the specificity of CA19-9 to differentiate between pancreatic cancer, cholangiocarcinoma, or other pancreatic lesions is not satisfying enough. Tumor cells secret abundant exosomes in the early stage. Circulating tumor cells are detected mainly in the advanced stage. Meanwhile, the role of non-coding RNA draws more and more attention in tumor area. Exosomes protect inside RNA from plasma RNase. Compared with long RNA, small RNA, including miRNA, snoRNA, tRNA, piRNA could exist more stably. By means of next-generation sequencing, we look forward to finding new exosomal small RNA biomarkers. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04636788
Study type Interventional
Source Huazhong University of Science and Technology
Contact Bin Cheng, Professor
Phone 13986097542
Email b.cheng@tjh.tjmu.edu.cn
Status Recruiting
Phase N/A
Start date November 1, 2020
Completion date November 1, 2022
View Details
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