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Antinociceptive Effect of Transauricular Electrical Vagal Nerve Stimulation — TVNS_TSP  

Pain, Acute Clinical Trial

Official title:
Antinociceptive Effect of Transauricular Electrical Vagal Nerve Stimulation and Its Underlying Mechanisms

Clinical Trial Summary

This investigation is going to study whether electrical tVNS applied at the cymba of auricular conchae reduces central sensitization of experimentally induced pain in comparison with electrical sham stimulation applied at the earlobes and whether the hypoalgesic effects of tVNS disappear after pharmacological block of muscarinic receptors. Also, this investigation will examine whether tVNS is associated with activation in brain areas, involved in processing of thermal pain stimuli and emotional and vegetative modulation of thermal pain in subjects who will respond with antinociceptive reaction to tVNS.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04448990
Study type Interventional
Source University Medicine Greifswald
Contact Taras Usichenko, MD, PhD
Phone +49 3834865893
Email taras@uni-greifswald.de
Status Not yet recruiting
Phase N/A
Start date May 2021
Completion date August 2023
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