Endovascular Denervation for the Treatment of Patients With Peripheral Arterial Disease — EDPAD  

PAD Clinical Trial

Official title: Endovascular Denervation for the Treatment of Patients With Peripheral Arterial Disease

Status Recruiting

Clinical Trial Summary

Sympathetic overactivity partly promotes the development of peripheral artery disease which mainly leads to ischemia of the lower limbs. Endovascular arterial denervation (ED) is a minimally invasive technique which could deliver Radiofrequency energy by a multi-electrode catheter to the Lower limb artery to restore Sympathetic activity. The purpose of this study is to evaluate the effects of multi-electrode radiofrequency ablation system on lower limb ischemia with PAD.

Clinical Trial Description

Peripheral arterial disease(PAD) show insufficient blood supply of diseased limbs, which causes intermittent claudication of lower limbs, reduced skin temperature, pain, and chronic progressive disease that still produces ulcer or necrosis. Some clinical studies have shown Sympathetic overactivity in the lower arterial ischemic disease. The multi-electrode radiofrequency ablation system can significantly reduce the excitability of sympathetic nerve, restore the normal response of sympathetic nerve, relieve the pain and discomfort of patients, effectively improve the symptoms of lower limb ischemia, and improve the quality of life of patients. ;

Related Conditions & MeSH terms

• PAD
• Peripheral Arterial Disease
• Peripheral Vascular Diseases

• NCT number: NCT05345431
• Study type: Interventional
• Source: Zhongda Hospital
• Contact: Gao-Jun Teng, MD
• Phone: +86 25 83272121
• Email: gjteng@seu.edu.cn
• Status: Recruiting
• Phase: N/A
• Start date: April 25, 2022
• Completion date: June 30, 2026